Oxidative Stress-Related Biomarkers in Postmenopausal Osteoporosis: A Systematic Review and Meta-Analyses.
Oxidative Stress-Related Biomarkers in Postmenopausal Osteoporosis: A Systematic Review and Meta-Analyses.
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绝经后骨质疏松症中氧化应激相关的生物标志物：系统评价和荟萃分析
DOI：
10.1155/2016/7067984
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发表时间：
2016
期刊：
影响因子：
--
通讯作者：
Huang S
中科院分区：
文献类型：
--
作者：
Zhou Q;Zhu L;Zhang D;Li N;Li Q;Dai P;Mao Y;Li X;Ma J;Huang S
大量研究表明，氧化应激(OS)在绝经后骨质疏松症(PO)的发生和发展中起着核心作用；然而，OS相关生物标志物与PO之间的关系却得到了相互矛盾的结果。这项荟萃分析旨在确定这些标记物与PO之间的关联，并探索可能解释这些结果不一致的因素。对相关数据库进行系统的文献检索。首先确定搜索词和选择标准，以确定并纳入在PO患者中检测到OS标志物的所有研究。我们用随机效应Meta分析和标准化均数差异和95%可信区间合并数据。共纳入17项研究，包括12个OS标记。结果表明，PO组红细胞超氧化物歧化酶(SOD)、过氧化氢酶(CAT)、总抗氧化状态(TAS)、过氧化氢(HY)、高级氧化蛋白产物(AOPP)、丙二醛(MDA)和维生素B12(VB12)与对照组比较无显著差异，而血浆/血清同型半胱氨酸(Hcy)和一氧化氮(NO)水平明显升高，而血浆/血清中SOD、谷胱甘肽过氧化物酶(GPX)、叶酸和总抗氧化能力(TAP)明显下降。综上所述，OS可能在PO的发病机制和临床病程中作为潜在的生物标志物。
Numerous studies suggested that oxidative stress (OS) played a central role in the onset and development of postmenopausal osteoporosis (PO); however, conflicting results were obtained as to the association of OS-related biomarkers and PO. This meta-analysis aimed to identify the association between these markers and PO, and explore factors that may explain the inconsistencies in these results. A systematic literature search was conducted in relevant database. Search terms and selection criteria were priorly determined to identify and include all studies that detected markers of OS in PO patients. We pooled data with a random effects meta-analysis with standardized mean differences and 95% confidence interval. Total 17 studies including 12 OS markers were adopted. The results showed that superoxide dismutase (SOD) in erythrocytes, catalase (CAT), total antioxidant status (TAS), hydroperoxides (HY), advanced oxidation protein products (AOPP), malondialdehyde (MDA), and vitamin B12 (VB12) in plasma/serum were not statistically different between the PO and control group, whereas significantly increased level of homocysteine (Hcy) and nitric oxide (NO), along with decreased SOD, glutathione peroxidase (GPx), folate, and total antioxidant power (TAP) in plasma/serum were obtained in the PO group. In summary, OS might serve as potential biomarkers in the etiopathophysiology and clinical course of PO.