Protective actions of tamoxifen and 4-hydroxytamoxifen against oxidative damage to human low-density lipoproteins: a mechanism accounting for the cardioprotective action of tamoxifen?
Protective actions of tamoxifen and 4-hydroxytamoxifen against oxidative damage to human low-density lipoproteins: a mechanism accounting for the cardioprotective action of tamoxifen?
复制标题
他莫昔芬和4-羟基他莫昔芬对人类低密度脂蛋白氧化损伤的保护作用：他莫昔芬心脏保护作用的机制？
作者：
H. Wiseman;G. Paganga;C. Rice;B. Halliwell
他莫昔芬和4-羟基他莫昔芬可保护分离的人低密度脂蛋白（LDL）免受铜离子依赖性脂质过氧化作用：4-羟基他莫昔芬比他莫昔芬或17 β-雌二醇更具保护作用。4-羟基他莫昔芬和17 β-雌二醇还可防止因暴露于铜离子而引起的LDL电泳迁移率增加，推测是通过保护LDL的脱辅基蛋白B免受氧化修饰。我们的观察可能有助于解释与他莫昔芬治疗和预防乳腺癌相关的心脏保护益处。
Tamoxifen and 4-hydroxytamoxifen protect isolated human low-density lipoproteins (LDLs) against copper-ion-dependent lipid peroxidation: 4-hydroxytamoxifen is more protective than tamoxifen or 17 beta-oestradiol. 4-Hydroxytamoxifen and 17 beta-oestradiol also prevent the increase in the electrophoretic mobility of LDL caused by exposure to copper ions, presumably by protection of the apoprotein B of LDL against oxidative modification. Our observations may help to account for the cardioprotective benefits reported to be associated with tamoxifen therapy and prophylaxis in breast cancer.