Down-regulation and gene hypermethylation of the 14-3-3 gamma in uterine leiomyoma.
Down-regulation and gene hypermethylation of the 14-3-3 gamma in uterine leiomyoma.
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DOI：
10.2741/4457
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发表时间：
2016-06
期刊：
影响因子：
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通讯作者：
Wenxiao Jiang;Hui Luo;Zhaojun Shen;Wenwen Zhang;Aixue Chen;Xueqiong Zhu
中科院分区：
文献类型：
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作者：
Wenxiao Jiang;Hui Luo;Zhaojun Shen;Wenwen Zhang;Aixue Chen;Xueqiong Zhu
We demonstrated that the expression of 14-3-3 gamma was lower in uterine leiomyomas compared to the adjacent normal myometrium. Here, we show that 14-3-3 gamma promoter is methylated more in leiomyomas than myometrium. The level of 14-3-3 gamma protein in leiomyomas did not change in respect to age, size, location, or the type of leiomyoma. ER-alpha, ER-beta, and PR proteins were also higher in leiomyomas and the level of these proteins negatively correlated with the level of 14-3-3 gamma protein. These results suggest that the hypermethylation of the 14-3-3 gene promoter accounts for the decreased 14-3-3 gamma in leiomyomas and that such a low level of expression may be involved in the pathogenesis of leiomyomas.
