Prognostic role of long noncoding RNA ZFAS1 in cancer patients: a systematic review and meta-analysis.
Prognostic role of long noncoding RNA ZFAS1 in cancer patients: a systematic review and meta-analysis.
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DOI：
10.18632/oncotarget.19162
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发表时间：
2017-11-21
期刊：
影响因子：
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通讯作者：
Qin F
中科院分区：
文献类型：
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作者：
Lan T;Lan X;Li G;Zheng Z;Zhang M;Qin F
长链非编码RNA ZFAS 1在恶性肿瘤的发生中起着重要作用。大量研究表明ZFAS 1在肿瘤组织中的表达水平明显高于癌旁正常组织。我们进行了一项荟萃分析，以研究ZFAS 1表达与癌症患者临床结局之间的相关性。检索PubMed、EMBASE、Web of Science、科克伦图书馆、中国知网、万方数据库中符合条件的文献。最终纳入了来自9项研究的841例患者。我们的研究结果表明，ZFAS 1表达增加与癌症患者的OS差显著相关（HR = 2.13，95% CI = 1.71-2.65，P < 0.001）。ZFAS 1高表达组RFS较低表达组短（HR = 2.00，95% CI = 1.45-2.77，P < 0.001）。临床病理参数分析表明，ZFAS 1表达增加与血管浸润显著相关（OR = 2.26，95%CI = 1.36-3.78，P = 0.002），淋巴结转移（OR = 2.98，95% CI = 2.12-4.19，P < 0.001）和晚期TNM分期（OR = 3.00，95% CI = 2.18-4.12，P < 0.001）。总之，lncRNA ZFAS 1可能作为癌症患者的预后生物标志物，并且ZFAS 1表达增加可能与癌症的晚期特征密切相关。
Long noncoding RNA ZFAS1 has been identified as a crucial role in the tumorigenesis of malignant tumors. Numerous studies reported that the expression levels of ZFAS1 in tumor tissues were dramatically higher than that in adjacent normal tissues. We conducted a meta-analysis to investigate the correlation between ZFAS1 expression and clinical outcomes of cancer patients. The databases of PubMed, EMBASE, Web of Science, Cochrane Library, CNKI and WanFang were retrieved for eligible studies. A total of 841 patients from 9 studies were eventually included. Our results demonstrated that increased ZFAS1 expression was significantly associated with poor OS in cancer patients (HR = 2.13, 95% CI = 1.71–2.65, P < 0.001). Patients with high ZFAS1 expression presented shorter RFS than those with low ZFAS1 expression (HR = 2.00, 95% CI = 1.45–2.77, P < 0.001). The clinicopathological parameters analysis demonstrated that increased ZFAS1 expression was significantly associated with vascular invasion (OR = 2.26, 95% CI = 1.36–3.78, P = 0.002), lymph node metastasis (OR = 2.98, 95% CI = 2.12–4.19, P < 0.001) and advanced TNM stage (OR = 3.00, 95% CI = 2.18–4.12, P < 0.001). In conclusion, lncRNA ZFAS1 might serve as a prognostic biomarker for cancer patients and increased ZFAS1 expression may be closely related to advanced characteristics of cancer.