REDUCED TUMOR-GROWTH AFTER LOW-DOSE IRRADIATION OR IMMUNIZATION AGAINST BLASTIC SUPPRESSOR T-CELLS
REDUCED TUMOR-GROWTH AFTER LOW-DOSE IRRADIATION OR IMMUNIZATION AGAINST BLASTIC SUPPRESSOR T-CELLS
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DOI：
10.1073/pnas.78.3.1809
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发表时间：
1981-01-01
期刊：
影响因子：
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通讯作者：
URBAIN, J
中科院分区：
文献类型：
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作者：
TILKIN, AF;SCHAAFLAFONTAINE, N;URBAIN, J
抑制性T细胞比其他淋巴细胞对辐射更敏感。人们试图通过低剂量照射来减少肿瘤生长。同基因DBA/2小鼠在[小鼠肥大细胞瘤] P815肿瘤细胞接种后6天接受全身照射（150 rad; 1 rad = 0.01 J/kg）。在轻度照射的小鼠中，肿瘤生长显著减少。尝试通过在2个不同系统中提高针对抑制性T细胞的免疫来减少同基因肿瘤生长。DBA/2小鼠用细胞毒性消失后收集的脾T细胞免疫，然后注射P815肿瘤细胞。这些小鼠对P815细胞产生非常高的初级细胞毒性。在注射[小鼠甲基胆蒽诱导的肉瘤] T2肿瘤细胞之前，针对母细胞抑制性T细胞免疫C57 BL/6小鼠。这些小鼠中的一些排斥肿瘤，而另一些则发展出比对照小鼠更小的肿瘤。这些结果可以解释的诱导抗独特型活性针对抑制性T淋巴细胞的免疫受体，因为免疫与母细胞抑制性T细胞从小鼠携带T2肿瘤不修改另一种肿瘤，T10的生长。
Suppressor T cells are much more radiosensitive than other lymphoid cells. An attempt was made to reduce tumor growth by low-dose irradiation. Syngeneic DBA/2 mice received whole-body irradiation (150 rad; 1 rad = 0.01 J/kg) 6 days after [mouse Mastocytoma] P815 tumor cells inoculation. Tumor growth is significantly reduced in mildly irradiated mice. An attempt was made to reduce syngeneic tumor growth by raising immunity against suppressor T cells in 2 different systems. DBA/2 mice were immunized against splenic T cells collected after disappearance of cytotoxicity and then injected with P815 tumor cells. These mice develop a very high primary cytotoxicity against P815 cells. C57BL/6 mice were immunized against blastic suppressor T cells, before injection of [mouse methylcholanthrene-induced Sarcoma] T2 tumor cells. Some of these mice reject the tumor and others develop smaller tumors than control mice. These results could be explained by the induction of antiidiotypic activity directed against the immunological receptors of suppressor T lymphocytes, because immunization with blastic suppressor T cells from mice bearing the T2 tumor does not modify the growth of another tumor, T10.