Age and its association with low insulin and high amyloid-β peptides in blood.
Age and its association with low insulin and high amyloid-β peptides in blood.
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DOI：
10.3233/jad-150428
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发表时间：
2016
期刊：
影响因子：
--
通讯作者：
Qiu WQ
中科院分区：
文献类型：
--
作者：
Li H;Zhu H;Wallack M;Mwamburi M;Abdul-Hay SO;Leissring MA;Qiu WQ
年龄是发展为阿尔茨海默病(AD)的主要危险因素，修改与年龄相关的因素可能有助于推迟疾病的发病。本研究的目的是探讨年龄与代谢因素与AD发病风险的关系。测定血浆胰岛素、胰淀素和淀粉样蛋白-β肽(A-β)浓度。我们用荧光素和生物素标记的Aβ40进一步测定了血清Aβ降解活性。观察载脂蛋白E4等位基因(ApoE4)与认知功能障碍的关系。受试者分为三个年龄组：60-70岁、70-80岁和≥80岁。我们发现，年龄越大，胰岛素浓度越低(p=0.001)，血浆A-β1-40浓度越高(p=0.004)。然而，年龄与另一种胰多肽--胰淀素的浓度无关，仅与Aβ1-42有微弱的相关性。在没有糖尿病、心血管疾病和中风的情况下，无论是否存在载脂蛋白E4和认知障碍，这些关系仍然存在。年龄、载脂蛋白E4与血清A-β降解活性呈负相关，而胰岛素与A-ApoE降解活性呈正相关。我们的研究提示，低胰岛素浓度和高Aβ40浓度是与AD风险相关的衰老因素。
Age is the major risk factor for developing Alzheimer’s disease (AD), and modifying age-related factors may help to delay the onset of the disease. The goal of this study was to investigate the relationship between age and the metabolic factors related to the risk of developing AD. The concentrations of insulin, amylin, and amyloid-β peptide (Aβ) in plasma were measured. We further measured the activity of serum Aβ degradation by using fluorescein- and biotin-labeled Aβ40. Apolipoprotein E4 allele (ApoE4) and cognitive impairment were characterized. Subjects were divided into three age groups: 60–70, 70–80, and ≥80 years old. We found that the older the subjects, the lower the concentration of insulin (p = 0.001) and the higher the concentration of Aβ1–40 (p = 0.004) in plasma. However, age was not associated with the concentration of another pancreatic peptide, amylin, and only marginally with Aβ1–42. These relationships remained in the absence of diabetes, cardiovascular disease, and stroke, and regardless of the presence of ApoE4 and cognitive impairment. Both age and ApoE4 were inversely associated with, while insulin was positively associated with, the activities of Aβ degradation in serum. Our study suggested that low concentration of insulin and high concentration of Aβ40 are aging factors related to the risk of AD.