Nano-structured antimicrobial surfaces: From nature to synthetic analogues
Nano-structured antimicrobial surfaces: From nature to synthetic analogues
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DOI：
10.1016/j.jcis.2017.07.021
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发表时间：
2017-12-15
影响因子：
9.9
通讯作者：
Ivanova, Elena P.
中科院分区：
文献类型：
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作者：
Elbourne, Aaron;Crawford, Russell J.;Ivanova, Elena P.
近年来，对抗菌表面的科学和工业兴趣显著增加。这种兴趣主要是为了应对工业和重要的医疗植入物表面的持续微生物污染。植入物表面的细菌污染通常导致植入物-组织界面处的感染，并且随着抗菌素耐药性水平的增加，这些感染的治疗变得更具挑战性。最近，已经发现许多天然存在的高纵横比表面形貌表现出高水平的杀生物功效。这些包括在昆虫翅膀表面形成的表皮脂质纳米结构，例如蝉和蜻蜓。已发现此类表面的抗微生物活性是基底的纳米级拓扑结构与附着的病原细胞之间物理相互作用的结果，这意味着该活性独立于生化表面功能。重要的是，这些理想的表面性质可以转化为合成的仿生表面，当模仿时，导致这种表面的抗微生物性质的显著增加。本文综述了最近的进展，了解这些机械抗菌机制的基础上，并讨论了正在朝着制造优化，生物相容性，合成类似物的进展。皇冠版权所有（C）2017由Elsevier Inc. All rights reserved.
The scientific and industrial interest in antimicrobial surfaces has significantly increased in recent times. This interest is largely in response to the persistent microbial contamination of industrial and, importantly, medical implant surfaces. Bacterial contamination of implant surfaces often leads to infection at the implant-tissue interface, and with the prevalence of increasing levels of antimicrobial resistance, the treatment of these infections is becoming far more challenging. Recently, many naturally occurring, high-aspect-ratio surface topographies have been discovered that exhibit high levels of biocidal efficacy. These include epicuticular lipid nano-architectures that are formed on the surfaces of insect wings, such as cicadae and dragonflies. The antimicrobial activity of such surfaces has been found to be a consequence of the physical interactions between the nanoscale topography of the substrate and the attaching pathogenic cells, meaning that the activity is independent of biochemical surface functionality. Importantly, these desirable surface properties can be translated to synthetic biomimetic surfaces, which, when mimicked, lead to a substantial increase in the antimicrobial properties of such surfaces. This paper reviews the recent advances in understanding the basis of these mechanical antimicrobial mechanisms, and discusses the progress being made towards the fabrication of optimised, biocompatible, synthetic analogues. Crown Copyright (C) 2017 Published by Elsevier Inc. All rights reserved.