Clinical usefulness of the mDIXON Quant the method for estimation of the salivary gland fat fraction: comparison with MR spectroscopy
Clinical usefulness of the mDIXON Quant the method for estimation of the salivary gland fat fraction: comparison with MR spectroscopy
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DOI：
10.1259/bjr.20160704
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发表时间：
2017-01-01
影响因子：
2.6
通讯作者：
Yoshiura, Kazunori
中科院分区：
文献类型：
--
作者：
Kise, Yoshitaka;Chikui, Toru;Yoshiura, Kazunori
Objective: To estimate the fat fraction (FF) in the salivary glands (SGs) by the mDIXON method and the H-1-MR spectroscopy (MRS) method, and to compare the results.Methods: 16 healthy volunteers were enrolled. mDIXON Quant and MRS (point-resolved spectroscopy: PRESS) with a single TE were employed to measure the FF in the parotid gland (PG) and submandibular gland (SMG). Multiple TEs were applied in 10 volunteers to correct for T-2 decay. In addition, we assumed that the 1.3 ppm peak accounted for 60% of the total fat peak and estimated the FF (MRS all) as a gold standard. On mDIXON Quant images, volumes of interest were set on the bilateral SGs and we obtained the FF (mDIXON) of each volume of interest.Results: There was a strong correlation between the results of the mDIXON Quant method and the MRS single TE) method (R-2 = 0.960, slope = 0.900). Using PRESS with multiple TEs, there was also a strong correlation between FF (mDIXON) and FF (MRS all) (R-2 = 0.963, slope = 1.18). FF (MRS all) was 24.9 +/- 12.7% in the PG and 4.5 +/- 3.0% in the SMG, while FF (mDIXON) was 29.4 +/- 16.2% in the PG and 6.4 +/- 4.7% in the SMG. There were no significant differences between the two methods, but the Bland-Altman plot showed that FF (mDIXON) was slightly larger than FF (MRS all) for small FF areas.Conclusion: The mDIXON Quant method could be clinically useful for evaluating the FF of SGs, but the absolute values need careful interpretation.Advance in knowledge: This study suggested the potential clinical usefulness of the mDIXON Quant method for the SGs.
