The menstrual cycle - Basic biology
The menstrual cycle - Basic biology
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DOI：
10.1196/annals.1429.018
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发表时间：
2008-01-01
期刊：
影响因子：
--
通讯作者：
Matzuk, Martin M.
中科院分区：
文献类型：
--
作者：
Hawkinsa, Shannon M.;Matzuk, Martin M.
月经周期的基本生物学是涉及下丘脑、垂体前叶、卵巢和子宫内膜的复杂、协调的事件序列。月经周期非常复杂，很容易受到压力、剧烈运动、饮食失调和肥胖等环境因素的干扰。此外，脆弱的 X 预兆、X 染色体异常和 1-磷酸半乳糖尿苷转移酶 (GALT) 点突变（半乳糖血症）等遗传影响也会导致月经周期的扰动。尽管并不完美，但小鼠模型已帮助识别和确认人类月经周期功能和功能障碍的其他成分和途径。
The basic biology of the menstrual cycle is a complex, coordinated sequence of events involving the hypothalamus, anterior pituitary, ovary, and endometrium. The menstrual cycle with all its complexities can be easily perturbed by environmental factors such as stress, extreme exercise, eating disorders, and obesity. Furthermore, genetic influences such as fragile X prermitations, X chromosome abnormalities, and galactose-1-phosphate uridyltransferase (GALT) point mutations (galactosemia) also contribute to perturbations of the menstrual cycle. Although not perfect, mouse models have helped to identify and confirm additional components and pathways in menstrual cycle function and dysfunction in humans.