Cognitive and physical activity and dementia A 44-year longitudinal population study of women
Cognitive and physical activity and dementia A 44-year longitudinal population study of women
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DOI：
10.1212/wnl.0000000000007021
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发表时间：
2019-03-19
期刊：
影响因子：
9.9
通讯作者：
Skoog, Ingmar
中科院分区：
文献类型：
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作者：
Najar, Jenna;Ostling, Svante;Skoog, Ingmar
目的探讨中年认知和体力活动是否与44年随访的女性痴呆和痴呆亚型风险降低相关。方法从1968年至2012年对800名年龄在38-54岁（平均年龄47岁）的女性进行了基于人群的样本随访。认知（艺术，智力，手工，宗教和俱乐部）和身体活动在基线进行评估。在随访期间，痴呆（n = 194），阿尔茨海默病（n = 102），血管性痴呆（n = 27），混合性痴呆（n = 41），痴呆伴脑血管疾病（n = 81）根据神经精神检查，知情人访谈，医院记录和登记数据的信息建立的标准进行诊断。采用考克斯回归模型，调整年龄、教育、社会经济状况、高血压、体重指数、吸烟、糖尿病、心绞痛、压力和重度抑郁症。结果我们发现，中年认知活动与随访期间总痴呆（风险比[HR] 0.66; 95%置信区间[CI] 0.49-0.89）和阿尔茨海默病（HR 0.54; 95% CI 0.36-0.82）的风险降低相关。中年体力活动与混合型痴呆（HR 0.43; 95%CI 0.22-0.86）和脑血管疾病痴呆（HR 0.47; 95%CI 0.28-0.78）风险降低相关。排除1990年之前患痴呆症的人（n = 21）后，结果相似，但体力活动也与总痴呆症风险降低相关（HR 0.67; 95%CI 0.46-0.99）。结论我们的研究结果表明，中年认知和体力活动与痴呆和痴呆亚型的风险降低独立相关。这些结果表明，这些中年活动可能在保持老年认知健康方面发挥作用。
Objective To investigate whether cognitive and physical activities in midlife are associated with reduced risk of dementia and dementia subtypes in women followed for 44 years. Methods A population-based sample of 800 women aged 38-54 years (mean age 47 years) was followed from 1968 to 2012. Cognitive (artistic, intellectual, manual, religious, and club) and physical activity were assessed at baseline. During follow-up, dementia (n = 194), Alzheimer disease (n = 102), vascular dementia (n = 27), mixed dementia (n = 41), and dementia with cerebrovascular disease (n = 81) were diagnosed according to established criteria based on information from neuropsychiatric examinations, informant interviews, hospital records, and registry data. Cox regression models were used with adjustment for age, education, socioeconomic status, hypertension, body mass index, cigarette smoking, diabetes mellitus, angina pectoris, stress, and major depression. Results We found that cognitive activity in midlife was associated with a reduced risk of total dementia (hazard ratio [HR] 0.66; 95% confidence interval [CI] 0.49-0.89) and Alzheimer disease (HR 0.54; 95% CI 0.36-0.82) during follow-up. Physical activity in midlife was associated with a reduced risk of mixed dementia (HR 0.43; 95% CI 0.22-0.86) and dementia with cerebrovascular disease (HR 0.47; 95% CI 0.28-0.78). The results were similar after excluding those who developed dementia before 1990 (n = 21), except that physical activity was then also associated with reduced risk of total dementia (HR 0.67; 95% CI 0.46-0.99). Conclusion Our findings suggests that midlife cognitive and physical activities are independently associated with reduced risk of dementia and dementia subtypes. The results indicate that these midlife activities may have a role in preserving cognitive health in old age.