Role of Innate Immunity in Initiation and Progression of Osteoarthritis, with Emphasis on Horses.
Role of Innate Immunity in Initiation and Progression of Osteoarthritis, with Emphasis on Horses.
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DOI：
10.3390/ani11113247
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发表时间：
2021-11-13
期刊：
影响因子：
--
通讯作者：
Wheat W
中科院分区：
文献类型：
--
作者：
Estrada McDermott J;Pezzanite L;Goodrich L;Santangelo K;Chow L;Dow S;Wheat W
骨关节炎(OA)是影响马和人的一种常见疾病。近年来，天然免疫系统在骨性关节炎发病和发展中的作用日益被人们所认识。这篇综述考察了先天性免疫系统在维持骨性关节炎炎症中的作用，从骨性关节炎和人类的动物模型中得出了跨物种的重要见解，并讨论了目前可用于治疗骨性关节炎的治疗免疫调节选择。骨关节炎(OA)是一种常见的疾病，病因多样，影响马、人和同伴动物。重要的是，骨性关节炎不是一种单一的疾病，而是一个由不同事件引发的疾病过程，包括急性创伤、关节结构不规则或重复超载以及随年龄增长而自发发展。我们对骨性关节炎发病机制的认识仍在发展中，人们越来越多地认为骨性关节炎是一种多因素疾病，在此过程中，天然免疫系统在调节和维持低级别炎症方面起着关键作用，从而导致持续性软骨损伤和破坏。滑膜和滑液中的巨噬细胞被认为是OA免疫过程的关键调节细胞，通过对局部和全身提示的反应，能够刺激和抑制关节炎症。本综述的目的是从人类研究、骨关节炎动物模型以及马的临床和研究研究中总结出先天免疫系统在骨性关节炎整体发病机制中的作用。这篇综述还讨论了目前可用于治疗骨性关节炎的各种治疗免疫调节选择及其作用机制。
Osteoarthritis (OA) is a common condition affecting horses and humans. The role of the innate immune system in the pathogenesis and progression of OA has been increasingly recognized in recent years. This review examines the function of the innate immune system in perpetuating inflammation seen in OA, drawing important insights across species from animal models of OA and humans, and discusses therapeutic immune modulatory options currently available to manage OA. Osteoarthritis (OA) is a common condition with diverse etiologies, affecting horses, humans, and companion animals. Importantly, OA is not a single disease, but rather a disease process initiated by different events, including acute trauma, irregular or repetitive overload of articular structures, and spontaneous development with aging. Our understanding of the pathogenesis of OA is still evolving, and OA is increasingly considered a multifactorial disease in which the innate immune system plays a key role in regulating and perpetuating low-grade inflammation, resulting in sustained cartilage injury and destruction. Macrophages within the synovium and synovial fluid are considered the key regulators of immune processes in OA and are capable of both stimulating and suppressing joint inflammation, by responding to local and systemic cues. The purpose of this review is to examine the role of the innate immune system in the overall pathogenesis of OA, drawing on insights from studies in humans, animal models of OA, and from clinical and research studies in horses. This review also discusses the various therapeutic immune modulatory options currently available for managing OA and their mechanisms of action.
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滑膜巨噬细胞和巨噬细胞产生的细胞因子在驱动聚集蛋白聚糖酶、基质金属蛋白酶和骨关节炎中其他破坏性和炎症反应中的作用。
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作者：
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作者：
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