Vascular remodelling and angiogenesis in asthma: Morphological aspects and pharmacological modulation
Vascular remodelling and angiogenesis in asthma: Morphological aspects and pharmacological modulation
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DOI：
10.2174/187152807780077273
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发表时间：
2007-03-01
期刊：
影响因子：
--
通讯作者：
Olivieri, Dario
中科院分区：
文献类型：
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作者：
Chetta, Alfredo;Zanini, Andrea;Olivieri, Dario
在支气管哮喘中，组织重塑可影响整个支气管壁，包括黏膜的血管成分。哮喘患者的支气管黏膜比健康受试者血管更丰富，表现为血管数量、尺寸以及血管面积增加。此外，血管变化可导致哮喘患者气道气流受阻。血管内皮生长因子是一种源自内皮细胞以及哮喘中大多数炎症细胞的介质，在血管重塑和血管生成中起主要作用。对肺活检的研究表明，抗哮喘药物可在不同程度上减少哮喘气道重塑中的血管成分。在哮喘药物中，吸入性糖皮质激素可有效逆转血管重塑的各个方面，如血管扩张、血管通透性增加和血管生成。更好地了解哮喘中的血管生成机制将有助于选择针对气道重塑这一方面的特定药物。本综述的目的是分析哮喘气道重塑中血管成分的形态学方面及其药理调节。
Tissue remodelling can affect the entire bronchial wall, including the vascular component of the mucosa, in bronchial asthma. The bronchial mucosa is more vascularized in asthmatic patients than in healthy subjects, showing an increase in the number and dimension of vessels and vascular area. In addition, vascular changes can contribute to obstructing the airway flow in asthma.Vascular Endothelial Growth Factor, a mediator derived from endothelial cells, but also from most inflammatory cells in asthma, plays a primary role in vascular remodelling and angiogenesis. Studies on lung biopsies showed that anti-asthma drugs can decrease to varying degrees the vascular component of airway remodelling in asthma. Among asthma medications, inhaled corticosteroids effectively reverse all aspects of vascular remodelling such as vasodilatation, increased vascular permeability and angiogenesis. A better knowledge of angiogenetic mechanisms in asthma will support the selection of specific medications acting on this aspect of airway remodelling.The aim of this review is to analyze the morphological aspects of the vascular component in airway remodelling in asthma, as well as its pharmacological modulation.