Lack of NK cells in lupus patients with renal involvement
Lack of NK cells in lupus patients with renal involvement
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DOI：
10.1177/096120339700600905
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发表时间：
1997-01-01
期刊：
影响因子：
2.6
通讯作者：
Isenberg, DA
中科院分区：
文献类型：
--
作者：
ErkellerYuksel, FM;Lydyard, PM;Isenberg, DA
我们之前已经表明，与正常人相比，SLE患者外周血中NK(CD3(-)/CD16(+)56)细胞的百分比和绝对数量显着降低。(1)活动性疾病患者的NK细胞水平非常低，并且这种减少也与肾脏受累的患者有关。我们现在使用双色免疫荧光和流式细胞术对 11 名患有 SLE 和肾脏受累的患者进行了一系列免疫表型研究。患者每三个月接受一次测试，平均测试三次。作为对照，九名没有肾脏受累的 SLE 患者在相似的时间间隔内进行了免疫表型分析；还测试了 11 个正常对照。主要淋巴细胞亚群（T、B 和 NK）在连续采血期间保持非常稳定。然而，肾脏受累患者的 NK 细胞群百分比均显着减少（5+/-6 vs 9+/-5，P
We have previously shown that patients with SLE have significantly lower percentages and absolute numbers of NK(CD3(-)/CD16(+)56) cells in their peripheral blood compared with normals.(1) Patients with active disease had very low levels of NK cells and the reduction was also associated with patients who had renal involvement. We have now performed a serial study immunophenotyping 11 patients with SLE and renal involvement using dual colour immunoflourescence and flow cytometry. Patients were tested every three months on an average of three occasions. As a control, nine SLE patients without renal involvement were immunophenotyped for similar intervals; 11 normal controls were also tested.Major lymphocyte subsets (T, B and NK) remained very stable during serial bleeds. However, the NK cell populations were decreased significantly in patients with renal involvement both as percentages (5+/-6 vs 9+/-5, P