Angiopoietin-like protein 8/betatrophin as a new determinant of type 2 diabetes remission after bariatric surgery
Angiopoietin-like protein 8/betatrophin as a new determinant of type 2 diabetes remission after bariatric surgery
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DOI：
10.1016/j.trsl.2017.03.001
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发表时间：
2017-06-01
影响因子：
7.8
通讯作者：
Vendrell, Joan
中科院分区：
文献类型：
--
作者：
Ejarque, Miriam;Borlaug, Marianne;Vendrell, Joan
这项工作旨在探讨血管生成素样蛋白 8 (ANGPTL8) 与代谢手术后体重减轻之间的联系。在横断面研究（n = 100）中，病态肥胖受试者的循环 ANGPTL8 浓度显着低于瘦受试者，并且病态肥胖的 2 型糖尿病 (T2DM) 患者的循环 ANGPTL8 浓度显着降低。相反，病态肥胖患者（尤其是 T2DM 患者）皮下脂肪组织（SAT）中的 ANGPTL8 表达较高，而内脏脂肪组织中的 ANGPTL8 表达没有变化。 ANGPTL8 循环水平的主要预测因子是 BMI 和 T2DM，而 SAT 中 ANGPTL8 的表达则由 T2DM 的存在决定。对患有 (n = 45) 和不患有 (n = 30) T2DM 的病态肥胖患者进行减肥手术前和减肥手术后 1 年的前瞻性队列研究显示，减肥手术后 1 年循环 ANGPTL8 水平显着升高。有趣的是，这种由基础 ANGPTL8 浓度预测的增量似乎是 T2DM 缓解的决定因素。总之，循环 ANGPTL8 水平与 SAT 表达呈反比关系。减肥手术后 ANGPTL8 基础水平低反弹。减肥后随访 1 个月时 ANGPTL8 浓度的增加是随访 1 年时 T2DM 缓解的重要预测因子。
This work aimed to explore the link between angiopoietin-like protein 8 (ANGPTL8) and weight loss after metabolic surgery. In the cross-sectional study (n = 100), circulating ANGPTL8 concentrations were significantly lower in morbidly obese than in lean subjects, and strikingly lower in morbidly obese patients with type 2 diabetes mellitus (T2DM). Conversely, ANGPTL8 expression in subcutaneous adipose tissue (SAT) was higher in morbidly obese patients, particularly in those with T2DM, whereas its expression in visceral adipose tissue was unchanged. The main predictors for circulating levels of ANGPTL8 were BMI and T2DM, whereas ANGPTL8 expression in SAT was determined by the presence of T2DM. The prospective cohort studies before and 1 year after bariatric surgery in morbidly obese patients with (n = 45) and without (n = 30) T2DM, revealed a significant increase of circulating ANGPTL8 levels 1 year after the bariatric surgery. Intriguingly, this increment, which was predicted by basal ANGPTL8 concentrations, appeared as a determinant of T2DM remission. In conclusion, circulating ANGPTL8 levels have an inverse relationship with SAT expression. Low basal levels of ANGPTL8 rebound after bariatric surgery. The increment in ANGPTL8 concentrations at 1 month of follow-up after weight loss emerged as a significant predictor of the T2DM remission at 1 year of follow-up.