Transcutaneous vagus nerve stimulation reduces spontaneous but not induced negative thought intrusions in high worriers
Transcutaneous vagus nerve stimulation reduces spontaneous but not induced negative thought intrusions in high worriers
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DOI：
10.1016/j.biopsycho.2019.01.014
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发表时间：
2019-03-01
影响因子：
2.6
通讯作者：
Verkuil, B.
中科院分区：
文献类型：
--
作者：
Burger, A. M.;Van der Does, W.;Verkuil, B.
担忧是焦虑症的主要组成部分。我们测试了非侵入性迷走神经刺激是否能减少高度焦虑者的负面思想入侵。忧虑是通过呼吸集中任务来评估的，该任务包括忧虑前阶段、忧虑诱导阶段和忧虑后阶段。在整个实验过程中，97名高度焦虑者被随机分配接受经皮电脉冲刺激迷走神经耳廓分支（tVNS）或耳垂分支（假刺激）。接受电视刺激的参与者在焦虑前的负面思想入侵显著减少，但在焦虑诱导后，电视刺激的效果好坏参半。一项探索性分析表明，tVNS条件下的参与者在焦虑诱导后不久更有可能报告负面思想入侵，但随着后焦虑期的持续，这种可能性越来越小。未观察到tVNS对RMSSD的影响。这些发现提供了初步的迹象，表明电视可能会减少令人担忧的想法的发生。
Worrying is a central component of anxiety disorders. We tested whether non-invasive vagus nerve stimulation reduces negative thought intrusions in high worriers. Worry was assessed with a Breathing Focus Task, which consists of a pre-worry period, a worry induction, and a post-worry period. Ninety-seven high worriers were randomly allocated to receive transcutaneous electrical stimulation of the auricular branch of the vagus nerve at the concha (tVNS), or of the earlobe (sham stimulation) throughout the lab session. Participants who received tVNS reported significantly fewer negative thought intrusions during the pre-worry period, but the effects of tVNS after the worry induction were mixed. An exploratory analysis indicated that participants in the tVNS condition were more likely to report negative thought intrusions shortly after the worry induction, but became less likely to do so as the post-worry period went on. No effects of tVNS on RMSSD were observed. These findings provide preliminary indications that tVNS may decrease the occurrence of worrisome thoughts.