The pseudoginsenoside F11 ameliorates cisplatin-induced nephrotoxicity without compromising its anti-tumor activity in vivo.
The pseudoginsenoside F11 ameliorates cisplatin-induced nephrotoxicity without compromising its anti-tumor activity in vivo.
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拟人参皂苷 F11 可改善顺铂诱导的肾毒性，同时不影响其体内抗肿瘤活性
DOI：
10.1038/srep04986
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发表时间：
2014-05-16
影响因子：
4.6
通讯作者：
Fu F
中科院分区：
文献类型：
--
作者：
Wang H;Kong L;Zhang J;Yu G;Lv G;Zhang F;Chen X;Tian J;Fu F
顺铂的临床应用因其相关的肾毒性而受到严重限制。在这项研究中，我们研究了假人参皂苷F11是否对顺铂引起的肾毒性有保护作用。为了澄清这一点，我们做了一个顺铂诱导的急性肾功能衰竭的体内模型。结果表明，F11预处理降低了顺铂升高的血尿素氮和肌酐水平，改善了组织病理学损伤。进一步研究表明，F11可抑制P53的活化，逆转顺铂诱导的Bax/Bcl2比值及抗氧化水平和自由基水平，从而抑制小管细胞凋亡。重要的是，F11在小鼠黑色素瘤和Lewis肺癌异种移植瘤模型中增强而不是抑制顺铂的抗肿瘤活性。我们的研究结果表明，F11与顺铂联合使用可能会减轻相关的肾毒性，而不会影响其治疗效果。这一发现为癌症的临床治疗提供了一种新的潜在策略。
The clinical use of cisplatin was severely limited by its associated nephrotoxicity. In this study, we investigated whether the pseudoginsenoside F11 had protective effects against cisplatin-induced nephrotoxicity. To clarify it, one in vivo model of cisplatin-induced acute renal failure was performed. The results showed that pretreatment with F11 reduced cisplatin-elevated blood urea nitrogen and creatinine levels, as well as ameliorated the histophathological damage. Further studies showed that F11 could suppress P53 activation, inverse the ratio of Bax/Bcl2 and the anti-oxidative and free radical levels induced by cisplatin, which in turn inhibited tubular cell apoptosis. Importantly, F11 enhanced rather than inhibited the anti-tumor activity of cispaltin in murine melanoma and Lewis lung cancer xenograft tumor models. Our findings suggested that administering F11 with cisplatin might alleviate the associated nephrotoxicity without compromising its therapeutic efficiency. This finding provides a novel potential strategy in the clinical treatment of cancer.
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DOI：
10.1124/jpet.110.165779
发表时间：
2010-08-10
影响因子：
3.5
作者：
Camano, Sonia;Lazaro, Alberto;Tejedor, Alberto
通讯作者：
Tejedor, Alberto
影响因子：
3.3
作者：
Çetin, R;Devrim, E;Durak, I
通讯作者：
Durak, I
影响因子：
2.9
作者：
Edelstein, Charles L.
通讯作者：
Edelstein, Charles L.
影响因子：
19.6
作者：
Humanes, Blanca;Lazaro, Alberto;Tejedor, Alberto
通讯作者：
Tejedor, Alberto
DOI：
10.1111/j.1600-0773.1995.tb00167.x
发表时间：
1995-06-01
期刊：
PHARMACOLOGY & TOXICOLOGY
影响因子：
--
作者：
RAVI, R;SOMANI, SM;RYBAK, LP
通讯作者：
RYBAK, LP