Laser desorption/fourier transform ion cyclotron resonance mass spectrometry: digoxin, digitoxin, and their reduced and sugar-hydrolyzed metabolites.
Laser desorption/fourier transform ion cyclotron resonance mass spectrometry: digoxin, digitoxin, and their reduced and sugar-hydrolyzed metabolites.
复制标题
激光解吸/傅里叶变换离子回旋共振质谱法：地高辛、洋地黄毒苷及其还原和糖水解代谢物。
DOI：
10.1002/bms.1200150510
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发表时间：
1988
期刊：
影响因子：
--
通讯作者：
Robertson,LW
中科院分区：
文献类型：
--
作者：
Shomo2nd,RE;Chandrasekaran,A;Marshall,AG;Reuning,RH;Robertson,LW
地高辛和地地黄毒素（治疗充血性心力衰竭最常用的处方药）及其14种二氢水解和糖水解代谢产物的质谱通过傅里叶变换离子循环共振（LD/FT/ICR）质谱仪的激光解吸/电离获得。最强烈的峰通常是假分子[M + K]+离子，但也观察到与1‐‐3糖和羟基损失相对应的片段离子。用一组样品参数和谱仪参数建立了16个化合物的LD/FT/ICR质谱。不存在矩阵峰。最后，LD/FT/ICR在404 <m/z< 819的质量范围内提供≈5 ppm的动态质量精度。
Mass spectra of digoxin and digitoxin (the most widely prescribed drugs for treatment of congestive heart failure) and a complete set of their 14 dihydro‐ and sugar‐hydrolyzed metabolites have been obtained via laser desorption/ionization with a Fourier transform ion cyclotron resonance (LD/FT/ICR) mass spectrometer. The most intense peak is typically the pseudomolecular [M + K]+ion, but fragment ions corresponding to loss of 1‐‐3 sugars and hydroxyls are also observed. LD/FT/ICR mass spectra for all 16 compounds were produced with a single set of sample and spectrometer parameters. No matrix peaks are present. Finally, LD/FT/ICR provides dynamic mass accuracy within ≈5 ppm throughout a mass range of 404 <m/z< 819.