A narrative review of the roles of muscle segment homeobox transcription factor family in cancer.
A narrative review of the roles of muscle segment homeobox transcription factor family in cancer.
复制标题
肌肉节段同源盒转录因子家族在癌症中的作用的叙述性回顾。
DOI：
10.21037/atm-21-220
复制
发表时间：
2021-05
影响因子：
--
通讯作者：
Chu X
中科院分区：
文献类型：
--
作者：
Liu C;Huang M;Han C;Li H;Wang J;Huang Y;Chen Y;Zhu J;Fu G;Yu H;Lei Z;Chu X
在各种癌症中都观察到了许多同源基因基因的放松管制，并在肿瘤进展中引起了功能意义。在这篇综述中，我们将重点介绍人类肌肉段同型（MSX）转录因子家族在肿瘤发生过程中的作用。通过复杂的下游调节机制，MSX转录因子是通过参与细胞增殖，细胞侵袭，细胞转移，细胞凋亡，细胞分化，肿瘤的耐药性，肿瘤干性和肿瘤血管生成的耐药性，通过参与细胞增殖，细胞凋亡，细胞分化，细胞分化，细胞分化，细胞凋亡，细胞分化，细胞凋亡，细胞分化和肿瘤血管生成，是MSX转录因子。此外，它们在癌症中的上游调节机制可能包括：基因突变和染色体像差； DNA甲基化和染色质修饰；通过非编码RNA进行调节；其他转录因子和翻译后修饰的调节。这些机制可以更好地理解为什么在肿瘤中表达MSX转录因子。值得注意的是，分子间相互作用和翻译后修饰可以调节MSX转录因子的转录活性。知道什么影响肿瘤中MSX转录因子的转录活性的原因也至关重要。 MSX转录因子家族的调节模式的系统摘要可能有助于进一步了解转录调控所涉及的机制，并为肿瘤进展提供了新的治疗方法。
Deregulation of many homeobox genes has been observed in various cancers and has caused functional implications in the tumor progression. In this review, we will focus on the roles of the human muscle segment homeobox (MSX) transcription factor family in the process of tumorigenesis. The MSX transcription factors, through complex downstream regulation mechanisms, are promoters or inhibitors of diverse cancers by participating in cell proliferation, cell invasion, cell metastasis, cell apoptosis, cell differentiation, drug resistance of tumors, maintenance of tumor stemness, and tumor angiogenesis. Moreover, their upstream regulatory mechanisms in cancers may include: gene mutation and chromosome aberration; DNA methylation and chromatin modification; regulation by non-coding RNAs; regulation by other transcription factors and post-translational modification. These mechanisms may provide a better understanding of why MSX transcription factors are abnormally expressed in tumors. Notably, intermolecular interactions and post-translational modification can regulate the transcriptional activity of MSX transcription factors. It is also crucial to know what affects the transcriptional activity of MSX transcription factors in tumors for possible interventions in them in the future. This systematic summary of the regulatory patterns of the MSX transcription factor family may help to further understand the mechanisms involved in transcriptional regulation and also provide new therapeutic approaches for tumor progression.
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DOI：
10.1158/1078-0432.ccr-15-1669
发表时间：
2016-06-15
期刊：
Clinical cancer research : an official journal of the American Association for Cancer Research
影响因子：
--
作者：
Bonito NA;Borley J;Wilhelm-Benartzi CS;Ghaem-Maghami S;Brown R
通讯作者：
Brown R
影响因子：
8.8
作者：
Gremel, G.;Ryan, D.;Rafferty, M.;Lanigan, F.;Hegarty, S.;Lavelle, M.;Murphy, I.;Unwin, L.;Joyce, C.;Faller, W.;McDermott, E. W.;Sheahan, K.;Ponten, F.;Gallagher, W. M.
通讯作者：
Gallagher, W. M.
影响因子：
--
作者：
De Cecco L;Negri T;Brich S;Mauro V;Bozzi F;Dagrada G;Disciglio V;Sanfilippo R;Gronchi A;D'Incalci M;Casali PG;Canevari S;Pierotti MA;Pilotti S
通讯作者：
Pilotti S
影响因子：
4.6
作者：
Horazna，Monika;Janeckova，Lucie;Korinek，Vladimir
通讯作者：
Korinek，Vladimir
影响因子：
5.6
作者：
Eppich, Simon;Kuhn, Christina;Heidegger, Helene Hildegard
通讯作者：
Heidegger, Helene Hildegard