First and Convergent Synthesis of Hybrid Sulfonophosphinopeptides
First and Convergent Synthesis of Hybrid Sulfonophosphinopeptides
复制标题
杂化磺基膦肽的首次聚合合成
DOI：
10.1021/ol901543y
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发表时间：
2009-09-03
期刊：
影响因子：
5.2
通讯作者：
Xu, Jiaxi
中科院分区：
文献类型：
--
作者：
He, Fengdan;Meng, Fanhua;Xu, Jiaxi
通过n保护的2-氨基烷磺酸酰胺、芳香醛和芳基二氯膦的mannich型反应，然后与氨基酯进行氨解，首先合成了杂化磺酰膦肽，并获得了满意的高产率。
Hybrid sulfonophosphinopeptides were first and convergently synthesized in satisfactory to good yields via the Mannich-type reaction of N-protected 2-aminoalkanesulfonamides, aromatic aldehydes, and aryldichlorophosphines and subsequent aminolysis with amino esters.