A DOUBLE-BLIND-STUDY OF THE EFFICACY OF METRONIDAZOLE GEL IN THE TREATMENT OF MALODOROUS FUNGATING TUMORS
A DOUBLE-BLIND-STUDY OF THE EFFICACY OF METRONIDAZOLE GEL IN THE TREATMENT OF MALODOROUS FUNGATING TUMORS
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DOI：
10.1016/0959-8049(92)90142-o
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发表时间：
1992-04-01
影响因子：
8.4
通讯作者：
COOMBES, RC
中科院分区：
文献类型：
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作者：
BOWER, M;STEIN, R;COOMBES, RC
进行了一项双盲安慰剂对照试验，以评估局部甲硝唑凝胶制剂在缓解真菌性肿瘤的难闻气味方面的价值。为期 5 天的试验之后是 6 天的试验，在此期间所有患者都接受了活性凝胶。患者和医务人员均进行了主观气味评估。共有 11 名患者入组，随后随机分组因整个 11 天内明显的总体获益而停止。在试验的最初双盲安慰剂对照阶段，没有出现支持积极治疗的显着趋势，并且没有观察到副作用。
A double-blind placebo-controlled trial was undertaken to assess the value of topical metronidazole gel preparation in the palliation of the offensive odour of fungating tumours. This 5 day trial was followed by a 6 day period during which all patients received the active gel. Subjective odour assessments were performed by both patients and medical staff. 11 patients were entered and the randomisation was then halted because of an obvious overall benefit over the whole 11 days. There was a non-significant trend in favour of the active treatment during the initial double-blind placebo-controlled phase of the trial, and no side-effects were observed.