Environmental novelty differentially affects c-fos mRNA expression induced by amphetamine or cocaine in subregions of the bed nucleus of the stria terminalis and amygdala
Environmental novelty differentially affects c-fos mRNA expression induced by amphetamine or cocaine in subregions of the bed nucleus of the stria terminalis and amygdala
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DOI：
10.1523/jneurosci.21-02-00732.2001
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发表时间：
2001-01-15
影响因子：
5.3
通讯作者：
Akil, H
中科院分区：
文献类型：
--
作者：
Day, HEW;Badiani, A;Akil, H
服用安非他明或可卡因的环境环境调节了它们的急性精神运动激活效应和诱导致敏的能力。在这里，我们报道了环境背景对雄性大鼠终末纹（BST）床核和杏仁核中苯丙胺和可卡因诱导的c-fos mRNA表达模式的不同影响。在杏仁核内侧和BST内侧后侧，暴露于新奇事物导致c-fos mRNA显著增加。在家中服用安非他明不会诱导c-fos mRNA，在新的环境中服用安非他明也不会增加c-fos mRNA的水平。在基底外侧和外侧杏仁核中，家中的安非他明或可卡因或暴露于新奇事物诱导c-fos mRNA。当在一个新的环境中给予安非他明或可卡因时，c-fos mRNA的反应显着增强。在杏仁核中央核（CEA）和BST卵圆形亚核（BSTov）中，在家服用安非他明可以显著增加c-fos mRNA的表达，而暴露在新奇环境中则没有什么影响。与研究的其他脑区相比，c-fos mRNA对安非他明在新环境和家庭环境中的反应明显更小。在“天然”和“新型”安非他明组中，BSTov和CEA中的c-fos mRNA主要在含脑啡肽的细胞中表达；与促肾上腺皮质激素释放激素共表达少见。这些数据表明，给予精神兴奋剂的环境有力而不同地改变了与药物强化和情感行为功能相关的边缘结构的反应。
The environmental context in which amphetamine or cocaine are administered modulates both their acute psychomotor activating effects and their ability to induce sensitization. Here we report that environmental context differentially affects patterns of amphetamine- and cocaine-induced c-fos mRNA expression in the bed nucleus of the stria terminalis (BST) and amygdala of male rats.In the medial amygdala and medial posterior BST, exposure to novelty resulted in a marked increase in c-fos mRNA. Amphetamine given at home did not induce c-fos mRNA, and when given in the novel environment, did not increase levels beyond that observed for novelty alone. In the basolateral and lateral amygdala, amphetamine or cocaine at home or exposure to novelty induced c-fos mRNA. When amphetamine or cocaine was given in a novel environment the c-fos mRNA response was significantly enhanced. In the central nucleus of the amygdala (CEA) and oval subnucleus of the BST (BSTov), amphetamine administration at home produced a robust increase in c-fos mRNA expression, whereas exposure to novelty had little effect. In contrast to other brain regions examined, the c-fos mRNA response to amphetamine in a novel versus home environment was significantly smaller. In both "home" and "novel" amphetamine groups, c-fos mRNA in the BSTov and CEA was predominantly expressed in enkephalin-containing cells; coexpression with corticotropin-releasing hormone was rare.These data suggest that the context in which psychostimulants are given powerfully and differentially alters the response of limbic structures that have been functionally implicated in drug reinforcement and emotional behaviors.