CREB modulates excitability of nucleus accumbens neurons
CREB modulates excitability of nucleus accumbens neurons
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DOI：
10.1038/nn1661
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发表时间：
2006-04-01
影响因子：
25
通讯作者：
Malenka, RC
中科院分区：
文献类型：
--
作者：
Dong, Y;Green, T;Malenka, RC
滥用药物会激活丘脑核（NAc）中的环磷酸腺苷反应元件结合蛋白（CREB）。在大鼠NAc中棘神经元（MSNs）中表达活性CREB增加了它们的兴奋性，而显性负性CREB则具有相反的作用。通过过度表达钾通道降低体内NAc MSN的兴奋性增强了对可卡因的运动反应，这表明CREB引起的NAc MSN兴奋性增加有助于限制对可卡因的行为敏感性。
Drugs of abuse cause activation of the cyclic AMP response element binding protein (CREB) in the nucleus accumbens (NAc). Expression of active CREB in rat NAc medium spiny neurons (MSNs) increased their excitability, whereas dominant-negative CREB had the opposite effect. Decreasing excitability of NAc MSNs in vivo by overexpression of potassium channels enhanced locomotor responses to cocaine, suggesting that the increased NAc MSN excitability caused by CREB helped to limit behavioral sensitivity to cocaine.