INVITRO METABOLISM OF JUVENILE HORMONE-III AND JUVENILE HORMONE-III BISEPOXIDE BY DROSOPHILA-MELANOGASTER AND MAMMALIAN CYTOSOLIC EPOXIDE HYDROLASE
INVITRO METABOLISM OF JUVENILE HORMONE-III AND JUVENILE HORMONE-III BISEPOXIDE BY DROSOPHILA-MELANOGASTER AND MAMMALIAN CYTOSOLIC EPOXIDE HYDROLASE
复制标题
DOI：
10.1016/0003-9861(91)90021-a
复制
发表时间：
1991-04-01
影响因子：
3.9
通讯作者：
HAMMOCK, BD
中科院分区：
文献类型：
--
作者：
CASAS, J;HARSHMAN, LG;HAMMOCK, BD
In vitrometabolism of juvenile hormone III (JH III) and juvenile hormone III bisepoxide was investigated using purified mouse liver cytosolic epoxide hydrolase (cEH) and cell fractions fromDrosophila melanogaster. JH III was metabolized faster than JH III bisepoxide by epoxide hydrolase activity inD. melanogastercell fractions and by cEH. After incubation with JH III bisepoxide, all cell fractions and cEH produced epoxy-diol,cis-andtrans-tetrahydrofuran-diols, and tetraol as metabolites. An increase in the concentration of cEH resulted in an increase in the proportion of tetraol as a JH III bisepoxide metabolite but this trend was not observed in theD. melanogastercell fractions. Differences between cell fractions in the metabolism of JH III and JH III bisepoxide suggests the presence of juvenile hormone epoxide hydrolase isozymes.
