Clinical significance of interleukin-18 for the diagnosis and prediction of disease course in systemic juvenile idiopathic arthritis
Clinical significance of interleukin-18 for the diagnosis and prediction of disease course in systemic juvenile idiopathic arthritis
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DOI：
10.1093/rheumatology/keaa634
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发表时间：
2021-05-01
期刊：
影响因子：
5.5
通讯作者：
Yachie, Akihiro
中科院分区：
文献类型：
--
作者：
Mizuta, Mao;Shimizu, Masaki;Yachie, Akihiro
Objective.目的探讨血清IL-18水平对系统性JIA（s-JIA）诊断及预测病程的临床意义。总体而言，116例s-JIA患者，151例其他疾病和20名健康对照进行了分析。对41例s-JIA患者从活动期至缓解期血清IL-18水平进行了纵向检测。采用酶联免疫吸附法检测血清IL-18水平，并与s-JIA的临床特征及病程进行比较。区分s-JIA与其他疾病的血清IL-18水平临界值为4800 pg/ml。在单周期病程的患者中，血清IL-18水平在非活动期稳定下降，缓解期持续低水平。相反，在慢性病程患者中，即使在非活动期，血清IL-18水平也持续升高。在多环病程的患者中，血清IL-18水平在疾病发作期间升高，在非活动期正常化。血清IL-18水平诊断s-JIA缓解的临界值为595 pg/ml。血清IL-18水平>4800 pg/ml可能有助于鉴别s-JIA与其他疾病。血清IL-18水平的监测可能有助于预测病程和评估缓解s-JIA。
Objective. To investigate the clinical significance of serum IL-18 levels for the diagnosis of systemic JIA (s-JIA) and to predict the disease course of s-JIA.Methods. Overall, 116 patients with s-JIA, 151 with other diseases and 20 healthy controls were analysed. Serum IL-18 levels were measured longitudinally in 41 patients with s-JIA from active phase through remission phase. Serum IL-18 levels were quantified via enzyme-linked immunosorbent assay and the results were compared with clinical features and the disease course of s-JIA.Results. The serum IL-18 level cut-off value for differentiation of s-JIA from other diseases was 4800 pg/ml. In patients with a monocyclic course, serum IL-18 levels steadily decreased during the inactive phase and low levels were sustained during remission. In contrast, in patients with a chronic course, elevated serum IL-18 levels were sustained even during the inactive phase. In patients with a polycyclic course, serum IL-18 levels were elevated during disease flares and normalized during the inactive phase. The serum IL-18 level cut-off value for diagnosis of remission in s-JIA was 595 pg/ml,Conclusion. Serum IL-18 levels of >4800 pg/ml may be useful for differentiating between s-JIA and other diseases. Monitoring of serum IL-18 levels might be useful for predicting the disease course and assessing remission in s-JIA.