Structure of the CLN3 gene and predicted structure, location and function of CLN3 protein.
Structure of the CLN3 gene and predicted structure, location and function of CLN3 protein.
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DOI：
10.1055/s-2007-973656
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发表时间：
1997-02
期刊：
影响因子：
1.4
通讯作者：
H. Mitchison;P. E. Taschner;Gabriel Kremmidiotis;D. F. Callen;Na Doggett;Terry J. Lerner;Janes Rb;Bonnie A. Wallace;P. Munroe;A. O'rawe;RM Gardiner;Sara E. Mole
中科院分区：
文献类型：
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作者：
H. Mitchison;P. E. Taschner;Gabriel Kremmidiotis;D. F. Callen;Na Doggett;Terry J. Lerner;Janes Rb;Bonnie A. Wallace;P. Munroe;A. O'rawe;RM Gardiner;Sara E. Mole
人类CLN3基因的基因组序列，这是有缺陷的青少年发病神经元蜡样脂褐质沉积症（巴滕病）正在划定使用各种方法。通过计算机辅助同源性搜索，已经鉴定了与人类疾病基因高度相似的酿酒酵母基因YHC 3（用于酵母同源物人类CLN 3）。拓扑预测表明CLN3蛋白含有六个跨膜片段。人类和酵母蛋白质之间的大多数相似性在于跨膜区段或沿着预测的蛋白质结构的沿着一面。
The genomic sequence of the human CLN3 gene, which is defective in juvenile onset neuronal ceroid lipofuscinosis (Batten disease) is being delineated using a variety of methods. A Saccharomyces cerevisiae gene, YHC3 (for Yeast Homologue to human CLN3), which is highly similar to the human disease gene, has been identified by computer-aided homology searching. Topology predictions indicate the CLN3 protein contains six transmembrane segments. Most similarity between the human and yeast proteins lies either in the transmembrane segments or along one face of the predicted protein structure.