Perinatal anoxia degrades auditory system function in rats.
Perinatal anoxia degrades auditory system function in rats.
复制标题
围产期缺氧会降低大鼠的听觉系统功能。
DOI：
10.1073/pnas.0509520102
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发表时间：
2005
影响因子：
11.1
通讯作者：
Merzenich,MM
中科院分区：
文献类型：
--
作者：
Strata,F;deIpolyi,AR;Bonham,BH;Chang,EF;Liu,RC;Nakahara,H;Merzenich,MM
对于语言障碍、自闭症、精神分裂症和其他残疾人群中记录的听觉和皮层处理速度降低的神经基础，我们知之甚少。虽然有强有力的证据表明遗传因素对病因学的贡献，但在相当大比例的病例中，表观遗传因素如围产期缺氧（PA）被认为是贡献者或因果关系。在这篇文章中，我们探讨了PA对听觉行为的这一基本方面和听觉系统功能的影响，在大鼠短暂围产期缺氧。PA大鼠增加了听觉阈值和降低处理效率记录在听觉行为任务。这些大鼠的听觉脑干反应的峰间间期略有增加，初级听觉皮层记录的刺激后时间直方图反应的潜伏期明显延长。后者与退化的初级听觉皮层感受野和破坏tonotopy。这些处理缺陷与有语言学习障碍和自闭症病史的儿童和成人记录的平行行为和生理缺陷一致。
Little is known about the neural bases of the reduced auditory and cortical processing speeds that have been recorded in language-impaired, autistic, schizophrenic, and other disabled human populations. Although there is strong evidence for genetic contributions to etiologies, epigenetic factors such as perinatal anoxia (PA) have been argued to be contributors, or causal, in a significant proportion of cases. In this article, we explored the consequences of PA on this elementary aspect of auditory behavior and on auditory system function in rats that were briefly perinatally anoxic. PA rats had increased acoustic thresholds and reduced processing efficiencies recorded in an auditory behavioral task. These rats had modestly increased interpeak intervals in their auditory brainstem responses, and substantially longer latencies in poststimulus time histogram responses recorded in the primary auditory cortex. The latter were associated with degraded primary auditory cortex receptive fields and a disrupted tonotopy. These processing deficits are consistent with the parallel behavioral and physiological deficits recorded in children and adults with a history of language-learning impairment and autism.