The potential use of bone marrow stromal cells for cochlear cell therapy
The potential use of bone marrow stromal cells for cochlear cell therapy
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DOI：
10.1097/wnr.0b013e3280287a9a
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发表时间：
2007-03-05
期刊：
影响因子：
1.7
通讯作者：
Ito, Juichi
中科院分区：
文献类型：
--
作者：
Sharif, Sadia;Nakagawa, Takayuki;Ito, Juichi
本研究探讨了骨髓基质细胞移植用于耳蜗细胞替代治疗的潜力。将增强型绿色荧光蛋白标记的骨髓基质细胞注射到小鼠正常耳蜗外淋巴间隙。移植后2周的组织学分析表明，移植细胞在耳蜗组织内定居，特别是在螺旋韧带和螺旋利姆布斯，虽然大多数移植位于外淋巴间隙。一些移植的细胞表达耳蜗缝隙连接蛋白连接蛋白26。这些研究结果表明，骨髓基质细胞提供治疗分子和耳蜗细胞的恢复，特别是在螺旋韧带和螺旋利姆布斯的潜力。
This study investigated the potential of bone-marrow stromal cell transplantation for cell replacement therapy in the cochlea. Bone-marrow stromal cells labeled with enhanced green fluorescent protein were injected into the perilymphatic space of normal cochleae in mice. Histological analysis 2 weeks after transplantation demonstrated that transplanted cells settled within the cochlear tissues, especially in the spiral ligament and the spiral limbus, although most transplants were located in the perilymphatic space. Some of the transplanted cells expressed the cochlear gap-junction protein connexin 26. These findings indicate the potential of bone-marrow stromal cells for delivering therapeutic molecules and for the restoration of cochlear cells, particularly in the spiral ligament and the spiral limbus.