The pleiotropic effects of excessive luteinizing hormone secretion in transgenic mice.
The pleiotropic effects of excessive luteinizing hormone secretion in transgenic mice.
复制标题
转基因小鼠黄体生成素分泌过多的多效性效应。
DOI：
10.1055/s-2007-984742
复制
发表时间：
2007
影响因子：
2.7
通讯作者：
Keri,RuthA
中科院分区：
文献类型：
--
作者：
Sutton,AmeliaLM;Keri,RuthA
促黄体激素（LH）是促性腺激素糖蛋白家族的成员，该家族还包括高度相关的人绒毛膜促性腺激素和卵泡刺激素。这些因素对于维持人类生育力的必要性几十年来一直为人所知。此外，血清LH水平升高与多囊卵巢综合征有关，表明LH的适当平衡对维持生殖功能至关重要。为了剖析体内异常LH信号传导的生物学后果，已经开发了几种过表达LH或具有增加的LH信号传导的基因工程小鼠模型。这些模型强调了严格调节LH水平对正常生殖功能的重要性，并揭示了LH和性腺激素在多种组织（包括卵巢、乳腺和垂体）肿瘤发生中的新作用。因此，LH信号改变的小鼠为理解正常生殖和各种病理条件提供了有价值的工具。
Luteinizing hormone (LH) is member of the glycoprotein hormone family of gonadotropins, which also includes the highly related human chorionic gonadotropin and follicle-stimulating hormone. The necessity of these factors for sustaining human fertility has been known for decades. In addition, elevated serum levels of LH have been associated with polycystic ovarian syndrome, suggesting that the appropriate balance of LH is critical for maintaining reproductive function. To dissect the biological consequences of aberrant LH signaling in vivo, several genetically engineered mouse models have been developed that overexpress LH or have increased LH signaling. These models underscore the importance of tightly regulated LH levels for normal reproductive function, and reveal novel roles for LH and gonadal hormones in tumorigenesis of multiple tissues, including the ovary, mammary gland, and pituitary. Thus, mice with altered LH signaling provide valuable tools in understanding normal reproduction and various pathological conditions.