Unusual dimeric chemical structure for a carboplatin analogue as a potential anticancer complex.
Unusual dimeric chemical structure for a carboplatin analogue as a potential anticancer complex.
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DOI：
10.1021/ic100638u
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发表时间：
2010-07
影响因子：
4.6
通讯作者：
Ming‐Jin Xie;Weiping Liu;L. Lou;Xi-zhu Chen;Qingsong Ye;Yao Yu;Q. Chang;Shuqian Hou
中科院分区：
文献类型：
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作者：
Ming‐Jin Xie;Weiping Liu;L. Lou;Xi-zhu Chen;Qingsong Ye;Yao Yu;Q. Chang;Shuqian Hou
An unexpected and unusual dimeric platinum(II) tetracarboxylate complex was obtained by the reaction of cis-[Pt(NH(3))(2)I(2)] with disilver dicarboxylate. The complex exhibits greater in vitro anticancer activity and lower toxicity in mice than its parent compound, carboplatin, and is therefore worthy of further evaluation as a potential antitumor dinuclear platinum agent.
