Central sensitization in medullary dorsal horn involves gap junctions and hemichannels
Central sensitization in medullary dorsal horn involves gap junctions and hemichannels
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DOI：
10.1097/wnr.0b013e328336eecb
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发表时间：
2010-02-17
期刊：
影响因子：
1.7
通讯作者：
Sessle, Barry J.
中科院分区：
文献类型：
--
作者：
Chiang, Chen Yu;Li, Zhaohui;Sessle, Barry J.
中枢致敏是导致急性和慢性疼痛状况的基本机制。我们以前的研究已经证明了芥子油应用于牙髓可以在大鼠延髓背角伤害性神经元中诱导出多巴胺能、嘌呤能和神经胶质依赖性的中枢敏化。这项研究表明，甘珀酸，一种有效的间隙连接和半通道阻滞剂，完全阻断了所有参数的芥子油诱导的中央敏化测试功能鉴定的髓背角伤害性神经元。这些结果代表的第一个证据表明，间隙连接和半通道可能有一个重要的作用，在介导的中枢敏化背角伤害性神经元，并可能占的传播以及发展的中枢敏化。NeuroReport 21：233-237（C）2010年威科健康垂直酒吧Lippincott威廉姆斯&威尔金斯。
Central sensitization is a fundamental mechanism contributing to acute and chronic pain conditions. Our previous studies have documented a glutamatergic, purinergic and glial-dependent central sensitization that can be induced in rat medullary dorsal horn nociceptive neurons by mustard oil application to the tooth pulp. This study showed that carbenoxolone, a potent gap junction and hemichannel blocker, completely blocked all parameters of mustard oil-induced central sensitization tested in functionally identified medullary dorsal horn nociceptive neurons. These results represent the first evidence suggesting that gap junctions and hemichannels may have a critical role in mediating central sensitization in dorsal horn nociceptive neurons and may account for the spread as well as development of central sensitization. NeuroReport 21:233-237 (C) 2010 Wolters Kluwer Health vertical bar Lippincott Williams & Wilkins.