Birth order and risk for schizophrenia:: a 31-year follow-up of the Northern Finland 1966 Birth Cohort
Birth order and risk for schizophrenia:: a 31-year follow-up of the Northern Finland 1966 Birth Cohort
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DOI：
10.1034/j.1600-0447.2001.00258.x
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发表时间：
2001-08-01
影响因子：
6.7
通讯作者：
Isohanni, M
中科院分区：
文献类型：
--
作者：
Kemppainen, L;Veijola, J;Isohanni, M
目的：北方芬兰1966年出生队列进行了研究，以调查出生顺序和schizophrenia.Method之间的关联：四个类别的出生顺序状态（第一个出生，最后出生，独生子女和其他状态）的形成，并与精神病发病率的数据。根据妊娠期不良反应、围产期并发症调整影响。结果：男性初产妇（1.5：95%，CI 1.0-2.2）和女性末产妇（1.3：95%，CI 1.0-2.2）患精神分裂症的危险性增加。95% CI 0.9-1.9）。男性末次出生者（Ratio 0.7，95%CI0.5 -0.9）和女性其他出生者（Ratio 0.6，95%CI0.3 -0.9）的危险性低于预期值。理论上的解释可能来自这里未确定的生物因素和/或与这些职位有关的心理压力。
Objective: The Northern Finland 1966 Birth Cohort was studied in order to investigate the association between birth order and schizophrenia.Method: Four categories of birth order status (first-born, last-born, only child and other status) were formed and linked to data on psychiatric morbidity. Effects were adjusted for wantedness of pregnancy, perinatal complications. maternal age at delivery, family type and number of siblings.Results: The risk for schizophrenia was elevated among male first-borns (ratio 1.5: 95%, CI 1.0-2.2)and female last-borns (ratio 1.3. 95% CI 0.9-1.9). The risk was lower than expected among male last-borns (ratio 0.7, 95'%, CI 0.5-0.9) and females belonging to other status (ratio 0.6; 95% CI 0.3-0.9).Conclusion: These results suggest that specific birth order status is an independent risk factor for schizophrenia. Theoretical explanations may arise from biological factors unidentified here and/or psychological stressors linked with these positions.