Notoamides A-D:: Prenylated indole alkaloids isolated from a marine-derived fungus, Aspergillus sp.
Notoamides A-D:: Prenylated indole alkaloids isolated from a marine-derived fungus, Aspergillus sp.
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Notoamides A-D:: 从一种源自海洋的真菌 Aspergillus sp.
DOI：
10.1002/anie.200604381
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发表时间：
2007-01-01
影响因子：
16.6
通讯作者：
Tsukamoto, Sachiko
中科院分区：
文献类型：
--
作者：
Kato, Hikaru;Yoshida, Takushi;Tsukamoto, Sachiko
海洋真菌具有丰富的结构新颖和生物活性的次级代谢产物，是一种重要的新型药物资源。[1]在寻找表现出令人感兴趣的活性的天然产物的过程中，[2]我们筛选了来自海洋生物的提取物的细胞毒性活性。本文报道了从海洋真菌Aspergillus sp.中分离得到的四个新的双异戊二烯基吲哚生物碱Notoamides AD（1-4）的分离、结构鉴定（包括绝对立体化学）和生物活性。从贻贝中分离出来的。在生物遗传学上，认为notoamides彼此相关，威廉姆斯等人成功地仿生合成了notoamides C（3）和D（4），并在后续论文中报道。[3]真菌，曲霉属，从日本海诺托半岛海域采集的贻贝中分离得到。将真菌在琼脂平板上发酵并用EtOH提取。将萃取物在减压下浓缩，并将水性残余物用EtOAc分配，然后用n-BuOH分配。的
Marine-derived fungi have proven to be rich sources of structurally novel and biologically active secondary metabolites, which are emerging as a significant new chemical resource for drug discovery.[1] During a search for natural products exhibiting pharmacologically interesting activities,[2] we screened extracts derived from marine organisms for cytotoxic activity. In this paper, we report the isolation, structure elucidation including absolute stereochemistry, and biological activities of four new doubly prenylated indole alkaloids, notoamides AD (1-4), from a culture of marine-derived fungus, Aspergillus sp., isolated from the common mussel, Mytilus edulis. Biogenetically, notoamides are assumed to be related each other, and Williams et al. succeeded in the biomimetic synthesis of notoamides C (3) and D (4), which are reported in the successive paper.[3] The fungus, Aspergillus sp., was separated from the mussel, Mytilus edulis, collected off Noto Peninsula in the Japan Sea. The fungus was fermented on agar plates and extracted with EtOH. The extract was concentrated under reduced pressure, and the aqueous residue was partitioned against EtOAc, and then n-BuOH. The