Effect of Altered Blood Plasma Osmolalities on Regional Brain Amino Acid Concentrations and Focal Seizure Susceptibility in the Rat
Effect of Altered Blood Plasma Osmolalities on Regional Brain Amino Acid Concentrations and Focal Seizure Susceptibility in the Rat
复制标题
改变血浆渗透压对大鼠脑部氨基酸浓度和局灶性癫痫易感性的影响
DOI：
10.1111/j.1471-4159.1986.tb04545.x
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发表时间：
1986
影响因子：
4.7
通讯作者：
Sharon F. Pruess
中科院分区：
文献类型：
--
作者：
C. Baxter;C. Wasterlain;Kristine L. Hallden;Sharon F. Pruess
摘要：血浆低渗或高渗显著改变了成年Sprague-道利大鼠内侧隔和海马脑组织中某些氨基酸的浓度。除了一些明显的例外，脑氨基酸浓度在低渗条件下降低，在高渗条件下增加。渗透变化和脑氨基酸变化似乎以几乎线性的方式彼此相关。大鼠和蟾蜍的比较表明，脑氨基酸浓度的变化模式在低渗血浆渗透压几乎是相同的两个物种。在高渗条件下，蟾蜍的变化要大得多。当通过水负荷使具有点燃致痫灶的大鼠低渗时，癫痫发作阈值显著降低。我们的数据表明，脑组织（特别是一些氨基酸神经递质和神经递质前体）的生化变化和癫痫发作的易感性的hypoglitically诱导的增加之间的可能关系。
Abstract: Blood plasma hypo‐ or hyperosmolality alters significantly the concentration of some amino acids in brain tissues of the medial septum and hippocampus of adult Sprague‐Dawley rats. With some notable exceptions, brain amino acid concentrations decreased under hypoosmotic conditions and increased under hyperosmotic conditions. Osmotic changes and brain amino acid changes appear to be related to each other in an almost linear fashion. A comparison of rats and toads indicates that the patterns of changes in brain amino acid concentrations in response to a hypoosmotic plasma osmolality were almost identical for both species. Changes achievable under hyperosmotic conditions were considerably greater in toads. When rats with kindled epileptogenic foci were made hypoosmotic by water‐loading, seizure thresholds decreased dramatically. Our data suggest a possible relationship between the hypoosmotically induced biochemical changes in brain tissues (especially some amino acid neurotransmitters and neurotransmitter precursors) and the hypoosmotically induced increase in seizure susceptibility.
注射高渗盐水或甘露醇可加速大鼠垂体神经中叶中脱水诱导的多巴胺合成激活。
影响因子：
4.1
作者：
Alper,RH;Moore,KE
通讯作者：
Moore,KE