Traditional Chinese herbal extracts inducing autophagy as a novel approach in therapy of nonalcoholic fatty liver disease.
Traditional Chinese herbal extracts inducing autophagy as a novel approach in therapy of nonalcoholic fatty liver disease.
复制标题
中药提取物诱导自噬作为治疗非酒精性脂肪肝的新方法
DOI：
10.3748/wjg.v23.i11.1964
复制
发表时间：
2017-03-21
影响因子：
4.3
通讯作者：
Li PY
中科院分区：
文献类型：
--
作者：
Liu C;Liao JZ;Li PY
非酒精性脂肪性肝病（NAFLD）是世界各地慢性肝病的主要原因之一，这是由于现代久坐和食物丰富的生活方式，其特征是肝脏中与酒精滥用以外的原因相关的过度脂肪积累。广泛认为胰岛素抵抗、脂质代谢功能障碍、内质网应激、氧化应激、炎症和凋亡/坏死都可能导致NAFLD。自噬是一种保护性的细胞内细胞器的自我消化，包括脂滴（脂肪吞噬），以响应压力，以维持稳态。除脂解作用外，脂肪吞噬作用是另一种脂质降解途径。据报道，受损的自噬也有助于NAFLD。一些研究表明，NAFLD的组织学特征（脂肪变性、小叶炎症和窦周纤维化）可能通过用传统中草药提取物治疗而得到改善，同时可能诱导自噬。本文将深入了解NAFLD中自噬的特征，以及白藜芦醇、枸杞多糖、薯蓣皂苷、佛手多酚组分、辣椒素和大蒜提取物等传统中草药提取物诱导自噬的相关作用/机制，这些提取物可能抑制NAFLD的进展。中药调节自噬/噬脂作用可能是治疗NAFLD的新途径，其分子机制有待进一步阐明。
Non-alcoholic fatty liver disease (NAFLD) is one of the leading causes of chronic liver diseases around the world due to the modern sedentary and food-abundant lifestyle, which is characterized by excessive fat accumulation in the liver related with causes other than alcohol abuse. It is widely acknowledged that insulin resistance, dysfunctional lipid metabolism, endoplasmic reticulum stress, oxidative stress, inflammation, and apoptosis/necrosis may all contribute to NAFLD. Autophagy is a protective self-digestion of intracellular organelles, including lipid droplets (lipophagy), in response to stress to maintain homeostasis. Lipophagy is another pathway for lipid degradation besides lipolysis. It is reported that impaired autophagy also contributes to NAFLD. Some studies have suggested that the histological characteristics of NAFLD (steatosis, lobular inflammation, and peri-sinusoid fibrosis) might be improved by treatment with traditional Chinese herbal extracts, while autophagy may be induced. This review will provide insights into the characteristics of autophagy in NAFLD and the related role/mechanisms of autophagy induced by traditional Chinese herbal extracts such as resveratrol, Lycium barbarum polysaccharides, dioscin, bergamot polyphenol fraction, capsaicin, and garlic-derived S-allylmercaptocysteine, which may inhibit the progression of NAFLD. Regulation of autophagy/lipophagy with traditional Chinese herbal extracts may be a novel approach for treating NAFLD, and the molecular mechanisms should be elucidated further in the near future.