[Study on Material Basis and Mechanism of Erzhi Wan prevent Alzheimer's disease by network pharmacology].
[Study on Material Basis and Mechanism of Erzhi Wan prevent Alzheimer's disease by network pharmacology].
复制标题
DOI：
10.19540/j.cnki.cjcmm.20170905.008
复制
发表时间：
2017-11-01
期刊：
影响因子：
--
通讯作者：
Zhou, Mao-Fu
中科院分区：
文献类型：
--
作者：
Huang, Li-Ping;Yan, Bo;Zhou, Mao-Fu
本研究旨在从网络药理学的角度探讨二至丸预防阿尔茨海默病的物质基础和作用机制。将阿尔茨海默病的关键靶点与二至丸化合物对接，利用Cytoscape 3.2.1软件建立药物-靶点-靶点-信号通路网络模型。30个化合物与阿尔茨海默病的关键靶点以及与Wnt、MAPK和PI3K-Akt-mTOR相关的三个关键通路具有很强的相互作用。从文献中可以确证二至丸中含有槲皮素、香叶醇、β-谷甾醇、橙花醇、淫羊藿醇等5种成分，初步揭示了二至丸治疗阿尔茨海默病的物质基础，并从三个信号通路方面探讨了其作用机制。网络药理学方法发现，二至丸治疗阿尔茨海默病的有效成分可能是槲皮素、香叶醇、β-谷甾醇、橙花醇和淫羊藿醇，其作用机制可能与Wnt、MAPK和PI3K-Akt-mTOR三条信号通路有关。
The present study is to explore the material basis and mechanism of Erzhi Wan the prevented Alzheimer's disease by using network pharmacology. The key target of Alzheimer's disease was docked with the Erzhi Wan compounds, and the drugs-target combined with target-signal pathway network model was established by Cytoscape 3.2.1 software. Thirty compounds have a strong interaction with key target of Alzheimer's disease and three key pathways related with Wnt, MAPK and PI3K-Akt-mTOR. There are 5 ingredients such as quercetin,geraniol,beta-sitosterol,nerol,eriodictyol that could be verified from literature.This result initially revealed the material basis for Erzhi Wan for Alzheimer's disease and the mechanism in terms of three signaling pathways. The network pharmacology method found that the active ingredients of Erzhi Wan for Alzheimer's disease may be quercetin,geraniol,beta-sitosterol,nerol,and eriodictyol, and the mechanism may be related to three signal pathways including Wnt, MAPK, and PI3K-Akt-mTOR.