Nodal Metastases Associated With Fusion Oncogenes Are Age Dependent in Young Adult Patients With Thyroid Cancer
Nodal Metastases Associated With Fusion Oncogenes Are Age Dependent in Young Adult Patients With Thyroid Cancer
复制标题
DOI：
10.1210/clinem/dgad458
复制
发表时间：
2023-12-21
影响因子：
5.8
通讯作者：
Ye, Lei
中科院分区：
文献类型：
--
作者：
Li, Haorong;Han, Rulai;Ye, Lei
背景：融合癌基因，特别是涉及RET或NTRK的融合癌基因，是甲状腺乳头状癌（PTC）的已知驱动因素。它们在儿科患者中普遍存在，并与侵袭性肿瘤行为相关。目的：探讨年轻成人PTC患者融合癌基因和侵袭性肿瘤行为的年龄依赖性。实验设计：我们检查了142例PTC患者的150个肿瘤，年龄在17岁至35岁之间，具有确定的肿瘤淋巴结转移分期。致癌驱动因子和甲状腺分化评分（TDS）通过靶组的DNA和RNA测序确定。在具有RET融合的PTC中进行转录组分析。结果：在150例PTC中，我们检测到BRAF V600 E（n = 105）、RET融合（n = 15）、NTRK3融合（n = 8）和BRAF融合（n = 4）。我们发现，当年龄分为3组时，融合癌基因与淋巴结转移相关：
Context: Fusion oncogenes, especially those involving RET or NTRK, are known drivers of papillary thyroid cancer (PTC). They are prevalent in pediatric patients and correlate with aggressive tumor behavior. Objective: We explored the age dependence of fusion oncogenes and aggressive tumor behavior in young adult PTC patients. Experimental Design: We examined 150 tumors from 142 PTC patients aged between 17 similar to 35 years old with established tumor-node-metastasis stages. Oncogenic drivers and the thyroid differentiation score (TDS) were determined by DNA and RNA sequencing of a target panel. Transcriptome analysis was performed in PTCs with RET fusions. Results: Among 150 PTCs, we detected BRAF V600E (n = 105), RET fusions (n = 15), NTRK3 fusions (n = 8), and BRAF fusions (n = 4). We found that fusion oncogenes were associated with nodal metastasis when age was tiered into 3 groups: