Bisphenol-A and chlorinated derivatives in adipose tissue of women
Bisphenol-A and chlorinated derivatives in adipose tissue of women
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DOI：
10.1016/j.reprotox.2007.06.007
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发表时间：
2007-08-01
影响因子：
3.3
通讯作者：
Olea, N.
中科院分区：
文献类型：
--
作者：
Fernandez, M. F.;Arrebola, J. P.;Olea, N.
双酚a （BPA）和氯代衍生物（Cl(x)BPA）在西班牙东南部妇女的脂肪组织中进行了调查。20份样品中有1份（55%）BPA含量高于检出限。在脂肪组织中，Cl(2)BPA含量最多（80%），占总氯代BPA含量的94.6%。脂肪组织中BPA、一氯双酚a （CIBPA）、二氯双酚a （Cl(2)BPA）、三氯双酚a （Cl(3)BPA）的平均+/- sd值分别为5.83 +/- 3.48、3.05 +/- 0.28、9.21 +/- 9.26和0.74 +/- 0.15 ng/g。在LOD以上未发现四氯双酚a （Cl(4)BPA）。没有关于人体脂肪组织中的双酚a或脂肪组织或血液中的氯(x)双酚a的公开数据，限制了比较。BPA水平（w/w）与其他人群血液中的发现（w/v）相似，低于胎盘组织中的水平（w/w）。由于双酚a及其Cl(x)双酚a具有雌激素模拟作用，因此需要进一步研究它们对人类健康的综合影响以及人类暴露的趋势。(C) 2007年Elsevier Inc.出版
Bisphenol-A (BPA) and chlorinated derivatives (Cl(x)BPA) were investigated in adipose tissue of women in Southeast Spain. BPA was above limit of detection (LOD) in I I out of 20 samples (55%). Among Cl(2)BPA, Cl(2)BPA was the most frequent (80%) and abundant, constituting 94.6% of total chlorinated BPA in adipose tissue. Mean +/- S.D. of BPA, monochloro-BPA (CIBPA), dichloro-BPA (Cl(2)BPA), and trichloro-BPA (Cl(3)BPA) were 5.83 +/- 3.48, 3.05 +/- 0.28, 9.21 +/- 9.26, and 0.74 +/- 0.15 ng/g of adipose tissue, respectively. No tetrachloro-BPA (Cl(4)BPA) was found above LOD. There are no published data on BPA in human adipose tissue or on Cl(x)BPA in adipose tissue or blood, limiting comparisons. BPA levels were similar (w/w) to findings in blood (w/v) in other populations and below levels reported in placenta tissue (w/w). Because of the estrogen mimicking effects of BPA and its Cl(x)BPA, further research is needed to explore their combined effects on human health and trends in human exposure. (C) 2007 Published by Elsevier Inc.