Zinc finger proteins in cancer progression.
Zinc finger proteins in cancer progression.
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DOI：
10.1186/s12929-016-0269-9
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发表时间：
2016-07-13
影响因子：
11
通讯作者：
Wang YC
中科院分区：
文献类型：
--
作者：
Jen J;Wang YC
锌指蛋白是人类基因组中最大的转录因子家族。锌指结构的多样性组合和功能使得锌指蛋白在发育、分化、代谢和自噬等生物学过程中用途广泛。在过去的几十年里，越来越多的证据揭示了锌指蛋白在癌症进展中的潜在作用。然而，锌指蛋白在癌症进展中的潜在机制在不同的癌症类型中不同，甚至在不同类型的应激下的相同癌症类型中也不同。本文就锌指蛋白在转录调控中的作用机制进行综述，并对锌指蛋白在肿瘤进展中的作用机制进行综述。在这篇综述中，我们还强调了进一步研究锌指蛋白在癌症进展中的潜在机制的重要性。
Zinc finger proteins are the largest transcription factor family in human genome. The diverse combinations and functions of zinc finger motifs make zinc finger proteins versatile in biological processes, including development, differentiation, metabolism and autophagy. Over the last few decades, increasing evidence reveals the potential roles of zinc finger proteins in cancer progression. However, the underlying mechanisms of zinc finger proteins in cancer progression vary in different cancer types and even in the same cancer type under different types of stress. Here, we discuss general mechanisms of zinc finger proteins in transcription regulation and summarize recent studies on zinc finger proteins in cancer progression. In this review, we also emphasize the importance of further investigations in elucidating the underlying mechanisms of zinc finger proteins in cancer progression.