CHEMOTHERAPEUTIC TREATMENT OF RECURRENT AND OR METASTATIC NASOPHARYNGEAL CARCINOMA - A RETROSPECTIVE ANALYSIS OF 40 CASES
CHEMOTHERAPEUTIC TREATMENT OF RECURRENT AND OR METASTATIC NASOPHARYNGEAL CARCINOMA - A RETROSPECTIVE ANALYSIS OF 40 CASES
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DOI：
10.1038/bjc.1993.312
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发表时间：
1993-07-01
影响因子：
8.8
通讯作者：
GEBBIA, N
中科院分区：
文献类型：
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作者：
GEBBIA, V;ZERILLO, G;GEBBIA, N
作者回顾了1984年7月至1992年7月在巴勒莫大学耳鼻咽喉科和化疗中心用顺铂为主的化疗治疗复发和/或转移性鼻咽癌40例。所有患者均接受包括高剂量顺铂（80- 100 mg/m-2）的方案治疗。组织学上鳞状细胞癌29例，未分化癌11例。39例患者可评价反应和毒性。总有效率为64%，其中完全有效率为20.5%，部分有效率为43.5%。完全缓解的平均持续时间为10.2 +个月，而部分缓解的平均持续时间为8.6 +个月。整个组的平均生存期为11.4 +个月，随访2年后有4例患者存活。转移性疾病患者与局部复发患者之间以及鳞状细胞NPC患者与未分化组织学患者之间的缓解率和生存率无统计学显著差异。所采用的方案通常耐受良好。这些数据证实NPC是一种对化疗高度敏感的肿瘤。然而，客观缓解的持续时间和生存率在很大程度上仍不令人满意。
Authors carried out a review of 40 cases of recurrent and/or metastatic nasopharyngeal carcinoma (NPC) treated with cisplatin-based chemotherapy at the Division of Othorhinolaryngology and the Service of Chemotherapy of the University of Palermo between July 1984 and July 1992. All patients were treated with regimens comprising high dose cisplatin (80- 100 mg m-2). Histologically there were 29 squamous cell and 11 undifferentiated NPC. Thirty-nine patients were evaluable for response and toxicity. The overall response rate was 64%, with a 20.5% complete response rate and a 43.5% partial response rate. The mean duration of complete reponses was 10.2 + months, while that of partial responses was 8.6 + months. The mean survival of the whole group was 11.4 + months, with four patients alive after 2 years of follow-up. No statistically significant difference in response rate and survival was found between patients with metastatic disease and those with locoregional recurrency, and between patients with squamous cell NPC and those with undifferentiated histology. The employed regimens have been generally well tolerated. These data confirm that NPC is a neoplasm highly reponsive to chemotherapy. However, duration of objective response and survival are still largely unsatisfactory.