Development of resistance during antibiotic therapy
Development of resistance during antibiotic therapy
复制标题
抗生素治疗期间耐药性的发展
DOI：
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复制
发表时间：
1987
期刊：
影响因子：
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通讯作者：
I. Braveny
中科院分区：
文献类型：
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作者：
D. Milatovic;I. Braveny
根据规定的标准通过查阅文献来评估抗生素治疗期间产生耐药性的频率。广谱青霉素的平均耐药率为 9.2%，第二代和第三代头孢菌素为 8.6%，拉氧头孢为 10.0%，亚胺培南为 4.7%，环丙沙星为 11.8%，氨基糖苷类为 13.4%。感染微生物耐药性的出现与大约一半病例的治疗失败有关，但接受氨基糖苷类药物治疗的患者除外，其中85%的病例出现耐药性导致治疗失败。讨论了联合治疗在耐药性发展方面可能带来的益处。
The frequency of development of resistance during antibiotic therapy was evaluated by reviewing the literature according to prescribed criteria. Mean resistance rates were calculated to be 9.2% for broad spectrum penicillins, 8.6% for second and third generation cephalosporins, 10.0% for latamoxef, 4.7% for imipenem, 11.8% for ciprofloxacin and 13.4% for aminoglycosides. Emergence of resistance of the infecting organism was associated with therapeutic failure in about half of the cases with the exception of patients treated with aminoglycosides in whom development of resistance resulted in treatment failure in 85 % of the cases. The possible benefit of combination therapy in terms of resistance development is discussed.
莫沙内酰胺加哌拉西林与莫沙内酰胺加阿米卡星治疗发热性粒细胞减少症患者的比较。
DOI：
10.1016/0002-9343(84)90100-1
发表时间：
1984
期刊：
The American journal of medicine
影响因子：
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作者：
Winston,DJ;Barnes,RC;Ho,WG;Young,LS;Champlin,RE;Gale,RP
通讯作者：
Gale,RP