Comparison of the efficacies of amphotericin B, fluconazole, and itraconazole against a systemic Candida albicans infection in normal and neutropenic mice
Comparison of the efficacies of amphotericin B, fluconazole, and itraconazole against a systemic Candida albicans infection in normal and neutropenic mice
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两性霉素 B、氟康唑和伊曲康唑对正常小鼠和中性粒细胞减少小鼠全身性白色念珠菌感染的疗效比较
DOI：
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发表时间：
1989
影响因子：
4.9
通讯作者：
R. van Furth
中科院分区：
文献类型：
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作者：
J. W. Van 't wout;H. Mattie;R. van Furth
我们在体外以及在正常和中性粒细胞减少小鼠的系统性念珠菌病动物模型中比较了新型三唑类抗真菌药物氟康唑和伊曲康唑与两性霉素 B 的疗效。向正常小鼠静脉注射10(4)个白色念珠菌或向中性粒细胞减少小鼠静脉注射10(3)个白色念珠菌后第1天，开始用氟康唑（2.5至20mg/kg，口服，每日两次）、伊曲康唑（10至40mg/kg，口服，每日两次）或两性霉素B（0.1至4mg/kg腹腔注射，每日一次）进行抗真菌治疗；用药2天。在正常小鼠中，根据肾脏培养的白色念珠菌数量进行评估，两性霉素 B 的治疗效果优于三唑。根据等效剂量，氟康唑比伊曲康唑更有效，尽管根据可用的游离药物量，伊曲康唑更有效。在中性粒细胞减少症小鼠中，两性霉素 B 的效果低于在正常小鼠中的效果，而三唑类药物在正常小鼠和中性粒细胞减少症小鼠中的效果相同。这是出乎意料的，因为体外数据显示两性霉素 B 具有很强的杀菌作用，而氟康唑和伊曲康唑在体外对白色念珠菌的生长只有很小的影响。
We compared the efficacies of the new triazole antifungal drugs fluconazole and itraconazole with that of amphotericin B in vitro and in an animal model of systemic candidiasis in normal and neutropenic mice. Antifungal treatment with fluconazole (2.5 to 20 mg/kg orally twice daily), itraconazole (10 to 40 mg/kg orally twice daily), or amphotericin B (0.1 to 4 mg/kg intraperitoneally once daily) was started 1 day after intravenous injection of 10(4) Candida albicans into normal mice or 10(3) C. albicans into neutropenic mice; the drugs were administered for 2 days. In normal mice the efficacy of treatment, which was assessed on the basis of the number of C. albicans cultured from the kidney, was greater for amphotericin B than for the triazoles. Fluconazole was more potent than itraconazole on the basis of equivalent doses, although itraconazole was more potent on the basis of the amount of free drug that was available. In neutropenic mice amphotericin B was less effective than it was in normal mice, whereas the triazoles were equally effective in normal and neutropenic mice. This was not expected, since in vitro data showed that amphotericin B was highly fungicidal, whereas both fluconazole and itraconazole had only a minimal effect on the growth of C. albicans in vitro.