2-CHANNEL BRAIN-STEM FREQUENCY-FOLLOWING RESPONSES TO PURE-TONE AND MISSING FUNDAMENTAL STIMULI
2-CHANNEL BRAIN-STEM FREQUENCY-FOLLOWING RESPONSES TO PURE-TONE AND MISSING FUNDAMENTAL STIMULI
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DOI：
10.1016/0168-5597(94)90100-7
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发表时间：
1994-07-01
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影响因子：
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通讯作者：
GALBRAITH, GC
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文献类型：
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作者：
GALBRAITH, GC
在两个不同的实验中，脑干频率跟随反应(FFR)被记录为纯音(200赫兹)和在时间精细结构和包络调制深度上不同的复杂的“缺失的基本”(MF)刺激。在水平和垂直偶极子取向的两个通道中同时记录到FFR。在两个实验中，水平电极是相同的(右-左耳)，但垂直构型不同(顶端-左耳；顶端相连的乳突)。水平通道产生了明确的FFR，以与听神经起始处一致的潜伏期进行音调刺激。然而，对MF刺激没有水平反应。后者的发现为MFS不直接编码在外周神经反应中的结论提供了电生理学支持。然而，垂直记录对音调和Mf刺激同样显示出明确的FFR。因此，缺失的基频在脑干中被记录下来。垂直潜伏期与外侧丘系水平的来源一致。FFR非常适合于阐明听觉信息处理的某些脑干机制。当比较水平和垂直偶极子方向的响应时，会得到重要的附加信息。因此，本结果首次提供了外周-脑干-MF编码二分法的诱发反应演示。
In 2 separate experiments the brain-stem frequency-following response (FFR) was recorded to a pure tone (200 Hz) and complex ''missing fundamental'' (MF) stimuli differing in temporal fine structure and envelope modulation depth. FFRs were simultaneously recorded in 2 channels with horizontal and vertical dipole orientations. Horizontal electrodes were identical in both experiments (right-left ear), but the vertical configuration was varied (vertex-left ear; vertex-linked mastoids). The horizontal channel yielded a well defined FFR to tone stimulation at a latency consistent with an origin along the auditory nerve. However, there was no horizontal response to MF stimulation. This latter finding provides electrophysiological support for the conclusion that MFs are not directly coded in the peripheral neural response. Vertical recordings, however, showed equally well defined FFRs to tone and MF stimuli. Thus, a representation of the missing fundamental frequency is registered in the brain-stem. Vertical latencies were consistent with a source at the level of the lateral lemniscus. The FFR is well suited to elucidate certain brain-stem mechanisms of auditory information processing. Important additional information results when responses are compared in horizontal and vertical dipole orientations. Thus, the present results provide the first evoked response demonstration of a peripheral-brain-stem dichotomy of MF coding.