Ratio of lethal and edema factors in rabbit systemic anthrax
Ratio of lethal and edema factors in rabbit systemic anthrax
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DOI：
10.1016/j.toxicon.2008.08.011
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发表时间：
2008-12-01
期刊：
影响因子：
2.8
通讯作者：
Tonello, Fiorella
中科院分区：
文献类型：
--
作者：
Dal Molin, Federica;Fasanella, Antonio;Tonello, Fiorella
炭疽芽孢杆菌分泌两种二元毒素：致死毒素（PA + LF）和水肿毒素（PA + EF），它们在炭疽的发病过程中起主要作用。它们的活动可以协同或相互干扰，这取决于细胞类型。因此，了解它们在体内的浓度比是至关重要的。本文首次测定了炭疽芽孢杆菌感染家兔血清中炭疽毒素成分LF/EF的浓度比。(C) 2008 Elsevier Ltd版权所有。
Bacillus anthracis secretes two binary toxins: lethal toxin (PA + LF) and edema toxin (PA + EF) that play a major role in the pathogenesis of anthrax. Their activities can synergize or interfere among each other, depending on the cell type. It is therefore fundamental to know their concentration ratio in vivo. Here, we report the first determination of the concentration ratio of anthrax toxin components LF/EF in the serum of rabbits infected with B. anthracis spores. (C) 2008 Elsevier Ltd. All rights reserved.