Chaotic behavior of renal sympathetic nerve activity: effect of baroreceptor denervation and cardiac failure.
Chaotic behavior of renal sympathetic nerve activity: effect of baroreceptor denervation and cardiac failure.
复制标题
肾交感神经活动的混乱行为：压力感受器去神经支配和心力衰竭的影响。
DOI：
10.1152/ajprenal.2000.279.3.f491
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发表时间：
2000
期刊：
影响因子：
--
通讯作者：
Sawin,LL
中科院分区：
文献类型：
--
作者：
DiBona,GF;Jones,SY;Sawin,LL
采用非线性动力学分析方法，对压力感受器完全失神经(窦-主动脉和心脏压力感受器去神经)和充血性心力衰竭(CHF)诱导清醒大鼠肾交感神经活动的混沌行为进行了研究。提取同步性肾交感神经放电峰值间期序列并进行分析。在对照大鼠中，这产生了一个系统，其关联维度在10-15的嵌入维度范围内收敛到一个较低的值，并且其最大Lyapunov指数为正。压力感受器完全去神经与系统关联维度的降低(前为2.65±0.27，后为1.64±0.17；P<0.01)和混沌行为的减少(最大Lyapunov指数：前为0.201±0.008比特/数据点，后为0.177±0.004比特/数据点，P<；0.02)有关。心力衰竭是一种以窦主动脉和心脏压力感受器对肾交感神经活动的调节受损为特征的状态，与相关维度的下降(对照3.41±0.23，CHF 2.62±0.26；P<；0.01)和混沌行为的减少(最大Lyapunov指数：0.205±0.048比特/数据点控制，0.136±0.033比特/数据点CHF，P&t；0.02)相关。这些结果表明，无论是生理上还是病理生理上，去掉窦主动脉和心脏压力感受器对肾交感神经活动的调节，都与系统关联维度的减少和混沌行为的减少有关。
Nonlinear dynamic analysis was used to examine the chaotic behavior of renal sympathetic nerve activity in conscious rats subjected to either complete baroreceptor denervation (sinoaortic and cardiac baroreceptor denervation) or induction of congestive heart failure (CHF). The peak interval sequence of synchronized renal sympathetic nerve discharge was extracted and used for analysis. In control rats, this yielded a system whose correlation dimension converged to a low value over the embedding dimension range of 10–15 and whose greatest Lyapunov exponent was positive. Complete baroreceptor denervation was associated with a decrease in the correlation dimension of the system (before 2.65 ± 0.27, after 1.64 ± 0.17;P< 0.01) and a reduction in chaotic behavior (greatest Lyapunov exponent: 0.201 ± 0.008 bits/data point before, 0.177 ± 0.004 bits/data point after,P< 0.02). CHF, a state characterized by impaired sinoaortic and cardiac baroreceptor regulation of renal sympathetic nerve activity, was associated with a similar decrease in the correlation dimension (control 3.41 ± 0.23, CHF 2.62 ± 0.26;P< 0.01) and a reduction in chaotic behavior (greatest Lyapunov exponent: 0.205 ± 0.048 bits/data point control, 0.136 ± 0.033 bits/data point CHF,P< 0.02). These results indicate that removal of sinoaortic and cardiac baroreceptor regulation of renal sympathetic nerve activity, occurring either physiologically or pathophysiologically, is associated with a decrease in the correlation dimensions of the system and a reduction in chaotic behavior.