Attention and sentence processing deficits in Parkinson's disease: the role of anterior cingulate cortex.
Attention and sentence processing deficits in Parkinson's disease: the role of anterior cingulate cortex.
复制标题
帕金森病的注意力和句子处理缺陷：前扣带皮层的作用。
DOI：
10.1093/cercor/2.6.513
复制
发表时间：
1992
期刊：
影响因子：
--
通讯作者：
Hurtig,HI
中科院分区：
文献类型：
--
作者：
Grossman,M;Crino,P;Reivich,M;Stern,MB;Hurtig,HI
帕金森病(PD)是一种复杂的神经退行性疾病，涉及运动障碍，与纹状体多巴胺能输入减少有关。智力缺陷也见于帕金森病，但这些困难的病理生理学机制还知之甚少。采用正电子发射断层扫描(PET)技术，研究了神经功能正常受试者在注意要求高的句子加工任务中的局部脑血流量(RCBF)。结果显示，在检测到一个形容词或句子中的某个特定施事时，大脑一组区域的rCBF显著增加，这些区域包括前扣带回皮质、左下额中皮质、左下颞枕叶皮质、后外侧颞叶皮质、左尾状核和左丘脑。我们通过使用两种正电子发射计算机断层扫描技术对帕金森病患者进行研究，发现了这个大脑网络中的缺陷。静息正电子发射计算机断层扫描研究显示，大脑前扣带回皮质的局部葡萄糖代谢与注意句子的细微语法方面的缺陷之间存在显著的相关性。用PET激活技术对帕金森病患者的研究表明，在执行形容词检测或制剂检测任务时，前扣带回和左额叶脑血流几乎没有变化。这些数据表明，前扣带回皮质的缺陷导致了帕金森病患者的认知障碍。
Parkinson's disease (PD) is a complex neurodegenerative condition involving a motor disorder that is related to reduced dopaminergic input to the striatum. Intellectual deficits are also seen in PD, but the pathophysiology of these difficulties is poorly understood. Regional cerebral blood flow (rCBF) was studied in neurologically intact subjects during the performance of attention-demanding, sentence processing tasks using positron emission tomography (PET). The results demonstrated significantly increased rCBF in a distributed set of cerebral regions during the detection of an adjective or a particular agent in a sentence, including anterior cingulate cortex, left inferior and middle frontal cortex, left inferior temporo-occipital cortex, posterolateral temporal cortex, left caudate, and left thalamus. We identified defects in this cerebral network by studying PD patients with two PET techniques. Resting PET studies revealed a significant correlation between regional cerebral glucose metabolism in anterior cingulate cortex and deficits in attending to subtle grammatical aspects of sentences. Studies of PD patients with the PET activation technique revealed little change in anterior cingulate and left frontal CBF during performance of the adjective detection or agent detection tasks. These data suggest that a defect in anterior cingulate cortex contributes to the cognitive impairments observed in PD.