Association Between Oxygen Saturation Targeting and Death or Disability in Extremely Preterm Infants in the Neonatal Oxygenation Prospective Meta-analysis Collaboration
Association Between Oxygen Saturation Targeting and Death or Disability in Extremely Preterm Infants in the Neonatal Oxygenation Prospective Meta-analysis Collaboration
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DOI：
10.1001/jama.2018.5725
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发表时间：
2018-06-05
影响因子：
120.7
通讯作者：
Simes, Robert J.
中科院分区：
文献类型：
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作者：
Aside, Lisa M.;Darlow, Brian A.;Simes, Robert J.
重要性极早产儿接受更多或更少的辅助供氧时，存在高氧血症和低氧血症的潜在益处和危害。目的比较脉搏血氧饱和度（Spo（2））测量的不同目标范围的氧饱和度对死亡或主要发病率的影响。Procursion计划对来自5项随机临床试验的个体受试者数据进行荟萃分析（从2005-2014年进行）招募妊娠28周前出生的婴儿。暴露Spo（2）目标范围较低（85%-89%）对较高（91%-95%）。主要结局和指标主要结局是死亡或严重残疾（双侧失明，耳聋，脑瘫被诊断为粗大运动功能分类系统或Bayley-III认知或语言评分≥ 2级
IMPORTANCE There are potential benefits and harms of hyperoxemia and hypoxemia for extremely preterm infants receiving more vs less supplemental oxygen.OBJECTIVE To compare the effects of different target ranges for oxygen saturation as measured by pulse oximetry (Spo(2)) on death or major morbidity.DESIGN, SETTING, AND PARTICIPANTS Prospectively planned meta-analysis of individual participant data from 5 randomized clinical trials (conducted from 2005-2014) enrolling infants born before 28 weeks' gestation.EXPOSURES Spo(2) target range that was lower (85%-89%) vs higher (91%-95%).MAIN OUTCOMES AND MEASURES The primary outcome was a composite of death or major disability (bilateral blindness, deafness, cerebral palsy diagnosed as >= 2 level on the Gross Motor Function Classification System, or Bayley-III cognitive or language score