Human papillomavirus infection and abnormal cytology of the anus in HIV-infected and uninfected adolescents
Human papillomavirus infection and abnormal cytology of the anus in HIV-infected and uninfected adolescents
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DOI：
10.1097/00002030-200302140-00004
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发表时间：
2003-02-14
期刊：
影响因子：
3.8
通讯作者：
Wilson, CM
中科院分区：
文献类型：
--
作者：
Moscicki, AB;Durako, SJ;Wilson, CM
目的：调查性活跃青少年中肛门人乳头瘤病毒（HPV）感染和肛门细胞学异常的患病率和风险。设计：来自感染和未感染 HIV 以及有高危性行为史的 13-18 岁青少年的患病率数据。方法：使用扩增技术检测 HPV DNA。肛门细胞学异常被定义为意义不明或更严重的非典型鳞状细胞。 结果：HIV 感染男孩 [28/58 (48%)] 和未感染男孩 [9/25 (36%)] 肛门 HPV 感染率相似 (P = 0.3)。但感染 HIV 的女孩 [59/183 (59%)] 高于未感染女孩 [11/82 (13%)]（P < 0.001）。肛周疣是两个男孩感染肛门 HPV 的风险 [比值比 (OR)，15.5；比值比 (OR)，15.5； 95% 置信区间 (CI)，1.6-149] 和女孩（OR，9.9；95% CI，1.9-51.3）。在没有肛门疣的受试者中，HIV 感染对于女孩来说很显着（OR，2.3；95% Cl，1.1-4.9），同性恋/双性取向对于男孩来说很显着（OR，5.2；95% Cl，1.3-20.6）。肛门细胞学异常在男孩中更为常见 [32/77 (41.6%)] 比女孩 [38/230 (16.5%)] (P < 0.001)，除了肛门 HPV 之外，独立危险因素还包括男孩的 HIV 阳性状态 (OR, 6.5; 95% Cl, 1.5-11.9) 以及女孩过去 3 个月内的性伴侣数量 (OR, 4.2; 95% Cl, 1.5-11.9)。 95% Cl, 1.5-11.9)。结论：肛门细胞学异常的强危险因素是男孩的 HIV 感染和肛门 HPV，以及女孩的肛门 HPV 和较多的性伴侣。结果表明，对于感染艾滋病毒的同性恋/双性恋男性，应考虑进行肛门细胞学筛查。 (C) 2003 年利平科特·威廉姆斯·威尔金斯。
Objective: To examine the prevalence of and risk for anal human papillomavirus (HPV) infection and abnormal anal cytology in sexually active adolescents.Design: Prevalence data from adolescents aged 13-18 years with and without HIV infection and with a history of high-risk sexual behavior.Methods: HPV DNA was detected using amplification techniques. Abnormal anal cytology was defined as atypical squamous cell of undetermined significance or worse.Results: Prevalence of anal HPV infection was similar in HIV-infected [28/58 (48%)] and uninfected [9/25 (36%)] boys (P = 0.3). but greater in HIV-infected [59/183 (59%)] than in uninfected [11/82 (13%)] girls (P < 0.001). Perianal warts were a risk for anal HPV in both boys [odds ratio (OR), 15.5; 95% confidence interval (CI), 1.6-149] and girls (OR, 9.9; 95% Cl, 1.9-51.3). In subjects without anal warts, HIV infection was significant for girls (OR, 2.3; 95% Cl, 1.1-4.9) and homosexual/bisexual orientation was significant for boys (OR, 5.2; 95% Cl, 1.3-20.6). Abnormal anal cytology was more common among boys [32/77 (41.6%)] than girls [38/230 (16.5%)] (P < 0.001) and in addition to anal HPV, independent risk factors were positive HIV status in boys (OR, 6.5; 95% Cl, 1.5-11.9) and number of partners within the past 3 months in girls (OR, 4.2; 95% Cl, 1.5-11.9).Conclusions: Strong risk factors for abnormal anal cytology were HIV infection and anal HPV in boys and anal HPV and higher number of sexual partners for girls. The results suggest that anal cytology screening should be considered in HIV infected homosexual/bisexual males. (C) 2003 Lippincott Williams Wilkins.