Antipyrine metabolism during hepatic regeneration in the rat.
Antipyrine metabolism during hepatic regeneration in the rat.
复制标题
大鼠肝再生过程中的安替比林代谢。
DOI：
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发表时间：
2008
期刊：
影响因子：
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通讯作者：
H. Pilsgaard
中科院分区：
文献类型：
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作者：
H. Poulsen;H. Pilsgaard
我们研究了 70% 部分肝切除术后大鼠的安替比林清除率以及 4-羟基安替比林、3-羟甲基安替比林和去甲安替比林的尿排泄量。安替比林清除率恢复速度比肝脏重量慢，但240小时后肝脏重量和安替比林清除率均达到对照值。在肝再生期间，安替比林向三种主要代谢物的转化减少，向3-羟甲基安替比林的转化比向其他代谢物的转化减少更多。安替比林清除率与肝脏重量密切相关（r = 0.81），表明肝再生过程中功能性肝质量与肝脏重量之间存在密切关系。
We investigated antipyrine clearance and urinary excretion of 4-hydroxyantipyrine, 3-hydroxymethylantipyrine and nor-antipyrine in rats after 70% partial hepatectomy. Antipyrine clearance recovered more slowly than liver weight but after 240 h both liver weight and antipyrine clearance had reached control values. During hepatic regeneration conversion of antipyrine to the three major metabolites was reduced, conversion to 3-hydroxymethylantipyrine being reduced more than conversion to the other metabolites. Antipyrine clearance was closely correlated to liver weight (r = 0.81), indicating a close relation between the functional hepatic mass and the liver weight during hepatic regeneration.