Proton magnetic resonance spectroscopic imaging in patients with extratemporal epilepsy
Proton magnetic resonance spectroscopic imaging in patients with extratemporal epilepsy
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DOI：
10.1111/j.1528-1157.1998.tb01371.x
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发表时间：
1998-03-01
期刊：
影响因子：
5.6
通讯作者：
Arnold, DL
中科院分区：
文献类型：
--
作者：
Stanley, JA;Cendes, F;Arnold, DL
目的：减少水平的N-乙酰天冬氨酸（NAA）在颞叶负责颞叶癫痫已观察到一致的质子磁共振spectroscopy（MRS）study.Methods：我们调查了质子MRS的潜力，以检测低NAA的颞叶以外的非病变部分颞外癫痫患者。对20例患者和16例正常对照者进行了额叶和中央/中央后区的质子磁共振波谱成像（MRSI）检查。通过广泛的临床EEG调查，包括记录每个患者的习惯性癫痫发作和10例患者的颅内EEG记录，确定癫痫发生区域。NAA/磷酸肌酸加肌酸（CRt）、NAA/含胆碱代谢物（Cho（t））和NAA/Cr-t + Cho（t））在整个光谱图像中均显著降低。此外，NAA比率的减少是更大的癫痫区域相比，nonepileptogenic regions，在EEG investigation.Conclusions：在体内质子MRSI的非病灶性部分颞外癫痫患者检测到的证据，广泛的神经元损伤或功能障碍，是最大的在该地区的癫痫发作的焦点。
Purpose: Reduced levels of N-acetylaspartate (NAA) in temporal lobes responsible for temporal lobe epilepsy have been observed consistently in proton magnetic resonance spectroscopy (MRS) studies.Methods: We investigated the potential of proton MRS to detect low NAA outside of the temporal lobes in patients with non-lesional partial extratemporal epilepsy. Proton MR spectroscopic imaging (MRSI) data of both frontal lobes and central/postcentral regions were obtained in 20 such patients and 16 normal control subjects. The epileptogenic region was determined by an extensive clinical-EEG investigation, including the recording of habitual seizures in each patient, and intracranial EEG recordings in 10 patients.Results: The relative NAA resonance intensities (i.e., NAA/ phosphocreatine plus creatine (CRt), NAA/choline-containing metabolites (Cho(t)) and NAA/Cr-t + Cho(t)), were all significantly reduced throughout the spectroscopic image as compared with that of the controls. Furthermore, reduction of the NAA ratios was greater in the epileptogenic region as compared with the nonepileptogenic regions, on EEG investigation.Conclusions: In vivo proton MRSI of patients with nonlesional partial extratemporal epilepsy detected evidence of widespread neuronal damage or dysfunction that was greatest in the region of seizure focus.