Role of centrifugal projections to the olfactory bulb in olfactory processing
Role of centrifugal projections to the olfactory bulb in olfactory processing
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DOI：
10.1101/lm.285706
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发表时间：
2006-09-01
影响因子：
2
通讯作者：
Linster, Christiane
中科院分区：
文献类型：
--
作者：
Kiselycznyk, Carly L.;Zhang, Steven;Linster, Christiane
虽然有证据表明，从皮质和神经调制结构到嗅球的反馈投射对于维持嗅球处理的振荡动力学至关重要，但动力学的变化如何与气味感知相关尚不清楚。利用嗅蒂的电损伤，在减少对嗅球的反馈输入的同时，保留来自嗅球的输出，我们在这里展示了对嗅球的反馈输入在形成气味-奖赏联系中的作用，但不是为了维持自发的气味辨别所反映的初级球气味表征。
While there is evidence that feedback projections from cortical and neuromodulatory structures to the olfactory bulb are crucial for maintaining the oscillatory dynamics of olfactory bulb processing, it is not clear how changes in dynamics are related to odor perception. Using electrical lesions of the olfactory peduncle, sparing Output from the olfactory bulb while decreasing feedback inputs to the olfactory bulb, we demonstrate here a role for feedback inputs to the olfactory bulb in the formation of odor-reward associations, but not for maintaining primary bulbar odor representations, as reflected by spontaneous odor discrimination.